4-(2-methoxyethoxy)-N-butyl-1,8-naphthalimide | 1325716-23-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-(2-methoxyethoxy)-N-butyl-1,8-naphthalimide
• 英文别名: 2-butyl-6-(2-methoxyethoxy)benzo[de]isoquinoline-1,3-dione
• CAS: 1325716-23-1
• 化学式: C₁₉H₂₁NO₄
• 分子量: 327.38
• InChiKey: TZVRZAOCFXWQHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙二醇甲醚 、 4-bromo-N-butylnaphthalimide 在 copper(l) iodide 、 potassium carbonate 作用下， 反应 3.0h， 以93%的产率得到4-(2-methoxyethoxy)-N-butyl-1,8-naphthalimide
  参考文献：
  名称：

  A novel fluorescent molecule based on 1,8-naphthalimide: synthesis, spectral properties, and application in cell imaging

  摘要：

  本研究合成了一种新型萘二甲酰亚胺分子，即 4-(2-甲氧基乙氧基)-N-丁基-1,8-萘二甲酰亚胺（MEBN），并对其进行了表征。研究了其在正己烷、甲苯、CHCl3 和 CH3OH 中的紫外-可见吸收和荧光发射光谱特性。其光学特性取决于溶剂的极性。研究了 MEBN 在细胞成像中的应用。

  DOI：

  10.1007/s11164-010-0214-6

文献信息

• Compound embodiments for hydrogen sulfide production and methods of making and using the same
  申请人：University of Oregon

  公开号：US11040942B1

  公开（公告）日：2021-06-22

  Disclosed herein are embodiments of a donor compound that releases COS and/or CS2, which can be converted to H2S. The donor compound embodiments described herein can be used to deliver H2S to a subject or a sample and further can be used to administer therapeutic agents. Methods of making and using the donor compound embodiments also are disclosed.

  本文披露了释放COS和/或CS2的供体化合物的实施例，这些化合物可以转化为H2S。本文描述的供体化合物实施例可用于向受试者或样品释放H2S，并且进一步可用于给药治疗剂。还披露了制备和使用供体化合物实施例的方法。
• COMPOUND AND DIMER COMPLEX EMBODIMENTS FOR SUPRAMOLECULAR SENSING
  申请人：UVic Industry Partnerships Inc.

  公开号：US20200407318A1

  公开（公告）日：2020-12-31

  Disclosed herein are embodiments of a compound that can be used as a supramolecular sensor for determining the presence of analytes (e.g., illicit drugs), and for identifying and/or quantifying the analytes. Also disclosed herein is a parallel synthesis method for making compound embodiments, as well as method embodiments for using the compound embodiments. Array embodiments comprising one or more compound embodiments disclosed herein also are described.

  本文披露了一种化合物的实施例，该化合物可用作超分子传感器，用于确定分析物（例如非法药物）的存在，并用于识别和/或定量分析物。还披露了一种用于制备化合物实施例的并行合成方法，以及用于使用化合物实施例的方法实施例。还描述了包括本文披露的一种或多种化合物实施例的阵列实施例。
• COMPOUNDS FOR THIOL-TRIGGERED COS AND/OR H2S RELEASE AND METHODS OF MAKING AND USING THE SAME
  申请人：University of Oregon

  公开号：US20210214368A1

  公开（公告）日：2021-07-15

  Disclosed herein are embodiments of a compound that is capable of releasing COS and/or H 2 S upon reaction with a thiol-containing compound. The compound embodiments also can produce a detectable signal (e.g., a fluorescent signal) substantially concomitantly with COS and/or H 2 S release and/or can release an active agent, such as a therapeutic agent. Methods of making and using the compound embodiments also are disclosed.
• A novel fluorescent molecule based on 1,8-naphthalimide: synthesis, spectral properties, and application in cell imaging
  作者：Haibo Xiao、Minjuan Chen、Guanghao Shi、Lei Wang、Hongyao Yin、Chong Mei

  DOI：10.1007/s11164-010-0214-6

  日期：2010.12

  A novel naphthalimide molecule, 4-(2-methoxyethoxy)-N-butyl-1,8-naphthalimide (MEBN), has been synthesized and characterized. The UV–visible absorption and fluorescence emission spectral properties in n-hexane, toluene, CHCl3, and CH3OH were studied. Its optical properties depend on solvent polarity. The application of MEBN in cell imaging was investigated.

  本研究合成了一种新型萘二甲酰亚胺分子，即 4-(2-甲氧基乙氧基)-N-丁基-1,8-萘二甲酰亚胺（MEBN），并对其进行了表征。研究了其在正己烷、甲苯、CHCl3 和 CH3OH 中的紫外-可见吸收和荧光发射光谱特性。其光学特性取决于溶剂的极性。研究了 MEBN 在细胞成像中的应用。