1-[2-[[1-[2-Bis[di(propan-2-yl)amino]phosphanyloxy-2-methylpropoxy]-2-methylpropan-2-yl]disulfanyl]ethyl]-2-methylguanidine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[2-[[1-[2-Bis[di(propan-2-yl)amino]phosphanyloxy-2-methylpropoxy]-2-methylpropan-2-yl]disulfanyl]ethyl]-2-methylguanidine
• 英文别名: 1-[2-[[1-[2-bis[di(propan-2-yl)amino]phosphanyloxy-2-methylpropoxy]-2-methylpropan-2-yl]disulfanyl]ethyl]-2-methylguanidine
• 化学式: C₂₄H₅₄N₅O₂PS₂
• 分子量: 539.8
• InChiKey: TZSVNLPAMBWLPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  34
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Functionalized phosphorodiamites for therapeutic oligonucleotide synthesis
  申请人：Petersen Scott G.

  公开号：US10022454B2

  公开（公告）日：2018-07-17

  Disclosed herein are compositions and methods for generating ribo-nucleic neutral (RNN) or deoxyribo-nucleic-neutral (DNN) polynucleotides with reduced anionic charge, for improved intracellular delivery. Also disclosed herein are methods of using RNN and DNN compositions.

  本文公开了用于生成阴离子电荷减少的核糖核中性（RNN）或脱氧核糖核中性（DNN）多核苷酸的组合物和方法，以改善细胞内递送。本文还公开了使用 RNN 和 DNN 组合物的方法。
• SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE
  申请人：Petersen Scott G.

  公开号：US20170224832A9

  公开（公告）日：2017-08-10

  Disclosed herein are compositions and methods for generating ribo-nucleic neutral (RNN) or deoxyribo-nucleic-neutral (DNN) polynucleotides with reduced anionic charge, for improved intracellular delivery. Also disclosed herein are methods of using RNN and DNN compositions.