2-(3-Azidopropoxy)ethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(3-Azidopropoxy)ethyl-trimethylazanium
• 英文别名: 2-(3-azidopropoxy)ethyl-trimethylazanium
• 化学式: C8H19N4O+
• 分子量: 187.26
• InChiKey: ULZIHPWVPGFIEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Compositions and Methods for Labeling and Imaging Phospholipids
  申请人：Salic Adrian

  公开号：US20120028290A1

  公开（公告）日：2012-02-02

  The present invention provides a method to label phospholipids in vivo based on the metabolic incorporation of an alkynyl- or azido-labeled metabolic precursor into phospholipids. The resulting phospholipids have alkynyl or azido moieties, which, upon reaction with a labeled azide or alkyne, respectively, form labeled compounds that can be visualized using optical or electron microscopy with high sensitivity and spatial resolution in cells or tissue. The present method provides a valuable tool for imaging phospholipid synthesis, turnover and subcellular localization in cultured cells as well as in animals.

  本发明提供了一种基于代谢前体的炔基或叠氮基标记磷脂的体内标记方法。所得到的磷脂具有炔基或叠氮基官能团，其与标记的叠氮或炔烃反应，形成标记化合物，可以在细胞或组织中使用光学或电子显微镜进行高灵敏度和空间分辨率的成像。本方法为在培养细胞和动物中成像磷脂合成、代谢和亚细胞定位提供了有价值的工具。
• US8987514B2
  申请人：——

  公开号：US8987514B2

  公开（公告）日：2015-03-24
• [EN] COMPOSITIONS AND METHODS FOR LABELING AND IMAGING PHOSPHOLIPIDS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE MARQUAGE ET L'IMAGERIE DES PHOSPHOLIPIDES
  申请人：HARVARD COLLEGE

  公开号：WO2010091142A1

  公开（公告）日：2010-08-12

  The present invention provides a method to label phospholipids in vivo based on the metabolic incorporation of an alkynyl- or azido-labeled metabolic precursor into phospholipids. The resulting phospholipids have alkynyl or azido moieties, which, upon reaction with a labeled azide or alkyne, respectively, form labeled compounds that can be visualized using optical or electron microscopy with high sensitivity and spatial resolution in cells or tissue. The present method provides a valuable tool for imaging phospholipid synthesis, turnover and subcellular localization in cultured cells as well as in animals.