(S)-2-(1-(4-(trifluoromethyl)phenyl)ethyl)naphthalene | 1424035-30-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-2-(1-(4-(trifluoromethyl)phenyl)ethyl)naphthalene
• 英文别名: 2-[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]naphthalene
• CAS: 1424035-30-2
• 化学式: C₁₉H₁₅F₃
• 分子量: 300.323
• InChiKey: AIMVZLAGPJZOTO-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (S)-(-)-1-(2-萘基)乙醇 在 4-二甲氨基吡啶 、 bis(1,5-cyclooctadiene)nickel (0) 、 sodium methylate 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 15.0h， 生成 (S)-2-(1-(4-(trifluoromethyl)phenyl)ethyl)naphthalene
  参考文献：
  名称：

  Nickel-Catalyzed Cross-Couplings of Benzylic Pivalates with Arylboroxines: Stereospecific Formation of Diarylalkanes and Triarylmethanes

  摘要：

  We have developed a stereospecific nickel-catalyzed cross-coupling of benzylic pivalates with arylboroxines. The success of this reaction relies on the use of Ni(cod)(2) as the catalyst and NaOMe as a uniquely effective base. This reaction has broad scope with respect to the arylboroxine and benzylic pivalate, enabling the synthesis of a variety of diarylalkanes and triarylmethanes in good to excellent yields and ee's.

  DOI：

  10.1021/ja312087x

文献信息

• Nickel-Catalyzed Cross-Couplings of Benzylic Pivalates with Arylboroxines: Stereospecific Formation of Diarylalkanes and Triarylmethanes
  作者：Qi Zhou、Harathi D. Srinivas、Srimoyee Dasgupta、Mary P. Watson

  DOI：10.1021/ja312087x

  日期：2013.3.6

  We have developed a stereospecific nickel-catalyzed cross-coupling of benzylic pivalates with arylboroxines. The success of this reaction relies on the use of Ni(cod)(2) as the catalyst and NaOMe as a uniquely effective base. This reaction has broad scope with respect to the arylboroxine and benzylic pivalate, enabling the synthesis of a variety of diarylalkanes and triarylmethanes in good to excellent yields and ee's.