3β,17β-Dihydroxy-androst-5-en-16-on | 1159-66-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β,17β-Dihydroxy-androst-5-en-16-on
• 英文别名: 5-Androsten-3b,17b-diol-16-one；(3S,10R,13S,17R)-3,17-dihydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,17-dodecahydrocyclopenta[a]phenanthren-16-one
• CAS: 1159-66-6；20592-50-1；24425-51-2
• 化学式: C₁₉H₂₈O₃
• 分子量: 304.43
• InChiKey: AKRBLZKRYPEVIK-IACDPKRHSA-N

物化性质

• 物理描述：
  Solid
• 熔点：
  203-205°C

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Therapeutic treatment of androgen receptor driven conditions
  申请人：Hollis-Eden Pharmaceuticals Inc.

  公开号：EP1832598A2

  公开（公告）日：2007-09-12

  The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.

  本发明提供了治疗前列腺癌等疾病的方法，或改善与前列腺癌相关的一种或多种症状的方法，或调节雄激素受体生物活性的制剂。本发明还提供了适用于治疗应用的方法和组合物。
• Androstenol derivatives as androgen receptor modulator
  申请人：Harbor BioSciences, Inc.

  公开号：EP2322182A1

  公开（公告）日：2011-05-18

  The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.

  本发明提供了治疗前列腺癌等疾病的方法，或改善与前列腺癌相关的一种或多种症状的方法，或调节雄激素受体生物活性的制剂。本发明还提供了适用于治疗应用的方法和组合物。
• Pharmaceutical Compositions
  申请人：Lardy A. Henry

  公开号：US20080021006A1

  公开（公告）日：2008-01-24

  The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
• Formulations
  申请人：Lardy A. Henry

  公开号：US20080058301A1

  公开（公告）日：2008-03-06

  The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
• Breast and Prostate Cancer Treatment Method
  申请人：Lardy Henry A.

  公开号：US20080176823A1

  公开（公告）日：2008-07-24

  The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.