β-Jonylamin | 43219-32-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: β-Jonylamin
• 英文别名: β-Ionylamin；3-Buten-2-amine, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-；(E)-4-(2,6,6-trimethylcyclohexen-1-yl)but-3-en-2-amine
• CAS: 43219-32-5
• 化学式: C₁₃H₂₃N
• 分子量: 193.332
• InChiKey: GMKBUWVORFVWQR-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-(2,6,6-三甲基-1-环己烯-1-基)-3-丁烯-2-醇 生成 β-Jonylamin
  参考文献：
  名称：

  Die Synthese von all-trans-Retinylamin und anderen Polyenaminen

  摘要：

  AbstractThe preparation of various polyene phthalimides using the azocarboxylate method is described. The imides are converted into the corresponding amines by reaction with hydrazine. In this way all‐trans‐retinylamine and β‐ionylamine have been obtained.

  DOI：

  10.1002/hlca.19730560523

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS
  申请人：Kubota Ryo

  公开号：US20090197967A1

  公开（公告）日：2009-08-06

  Provided herein are compositions and methods for treating ophthalmic diseases and disorders. Compositions comprising retinylamine derivative compounds provided herein are useful for treating and preventing ophthalmic diseases and disorders, including diabetic retinopathy diabetic maculopathy, diabetic macular edema, retinal ischemia, ischemia-reperfusion related retinal injury, and metabolic optic neuropathy.
• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT POUR MALADIES ET TROUBLES OPHTALMIQUES
  申请人：ACUCELA INC

  公开号：WO2007089673A2

  公开（公告）日：2007-08-09

  (EN) Provided herein are compositions and methods for treating ophthalmic diseases and disorders. Compositions comprising retinylamine derivative compounds provided herein are useful for treating and preventing ophthalmic diseases and disorders, including diabetic retinopathy diabetic maculopathy, diabetic macular edema, retinal ischemia, ischemia-reperfusion related retinal injury, and metabolic optic neuropathy.(FR) L'invention concerne des compositions et des méthodes pour traiter des maladies et des troubles ophtalmiques. Lesdites compositions comprennent des composés dérivés de la rétinylamine et sont utilisées pour traiter et prévenir des maladies et des troubles ophtalmiques, y compris une rétinopathie diabétique, une maculopathie diabétique, un œdème maculaire diabétique, une ischémie rétinienne, une lésion rétinienne d'ischémie de reperfusion, et une neuropathie optique métabolique.
• Die Synthese von all-trans-Retinylamin und anderen Polyenaminen
  作者：Frank Kienzle

  DOI：10.1002/hlca.19730560523

  日期：1973.7.18

  AbstractThe preparation of various polyene phthalimides using the azocarboxylate method is described. The imides are converted into the corresponding amines by reaction with hydrazine. In this way all‐trans‐retinylamine and β‐ionylamine have been obtained.