1-Methyl-3,4-dihydro-1,6-naphthyridin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-Methyl-3,4-dihydro-1,6-naphthyridin-2-one
• 英文别名: 1-methyl-3,4-dihydro-1,6-naphthyridin-2-one
• 化学式: C₉H₁₀N₂O
• 分子量: 162.19
• InChiKey: QUFHNOBIQJYAPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• INHIBITORS OF JUN N-TERMINAL KINASE
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP2393806B1

  公开（公告）日：2017-10-25
• TREATMENT OF FIBROTIC DISORDERS WITH JUN N-TERMINAL KINASE INHIBITORS
  申请人：Imago Pharmaceuticals, Inc.

  公开号：US20190231751A1

  公开（公告）日：2019-08-01

  The present disclosure provides a method of treating diseases, conditions or disorders associated with fibrosis in a mammal using inhibitors of the Jun N-terminal kinase (JNK) pathway. The present disclosure in particular provides methods of treating diseases, conditions or disorders associated with fibrosis using a specific class of small molecule JNK inhibitors.