1-(4-Methoxyphenyl)-1-(1-naphthalen-1-ylethyl)hydrazine | 880647-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(4-Methoxyphenyl)-1-(1-naphthalen-1-ylethyl)hydrazine
• 英文别名: 1-(4-methoxyphenyl)-1-(1-naphthalen-1-ylethyl)hydrazine
• CAS: 880647-73-4
• 化学式: C₁₉H₂₀N₂O
• 分子量: 292.381
• InChiKey: XFZMIRFIIJAJQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(4-Methoxyphenyl)-1-(1-naphthalen-1-ylethyl)hydrazine 、 4-chloro-2-methyl-butanal 以 异丙醇 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Diastereoselective Fischer-Type Pyrroloindole Synthesis and Its Application to the Synthesis of Chiral Pyrroloindole Alkaloids

  摘要：

  Facile access to optically active pyrroloindoles by Fischer-type pyrroloindole synthesis is investigated. The reaction using chiral hydrazines prepared from commercially available chiral amines proceeded with diastereoselective cyclization (up to 70% de), and a short-step conversion of the cycloadducts to (-)-desoxyeseroline and pyrroloindole alkaloids was achieved.

  DOI：

  10.3987/com-05-s(k)71
• 作为产物：
  描述：

  N-(4-methoxyphenyl)-1-(α-naphthyl)ethylamine 在 盐酸 、 lithium aluminium tetrahydride 、 sodium nitrite 作用下， 生成 1-(4-Methoxyphenyl)-1-(1-naphthalen-1-ylethyl)hydrazine
  参考文献：
  名称：

  Diastereoselective Fischer-Type Pyrroloindole Synthesis and Its Application to the Synthesis of Chiral Pyrroloindole Alkaloids

  摘要：

  Facile access to optically active pyrroloindoles by Fischer-type pyrroloindole synthesis is investigated. The reaction using chiral hydrazines prepared from commercially available chiral amines proceeded with diastereoselective cyclization (up to 70% de), and a short-step conversion of the cycloadducts to (-)-desoxyeseroline and pyrroloindole alkaloids was achieved.

  DOI：

  10.3987/com-05-s(k)71

文献信息

• Diastereoselective Fischer-Type Pyrroloindole Synthesis and Its Application to the Synthesis of Chiral Pyrroloindole Alkaloids
  作者：Atsushi Nishida、Satoru Ushigome、Ayako Sugimoto、Shigeru Arai

  DOI：10.3987/com-05-s(k)71

  日期：——

  Facile access to optically active pyrroloindoles by Fischer-type pyrroloindole synthesis is investigated. The reaction using chiral hydrazines prepared from commercially available chiral amines proceeded with diastereoselective cyclization (up to 70% de), and a short-step conversion of the cycloadducts to (-)-desoxyeseroline and pyrroloindole alkaloids was achieved.