N,3-dimethyloctan-3-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,3-dimethyloctan-3-amine
• 化学式: C₁₀H₂₃N
• 分子量: 157.3
• InChiKey: QNGKSBLRABAUCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Optimal Interstrand Bridge for Collagen Mimics
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20190119355A1

  公开（公告）日：2019-04-25

  Novel collagen-mimetic peptides are disclosed comprising the formula (Xaa-Yaa-Gly) n , where the amino acid at one of the Xaa positions is substituted with a homocysteine residue. Also disclosed are multi-stranded novel collagen-mimetic peptides comprising a first strand as described above that is covalently bonded with a disulfide bridge to a second strand comprising the formula (Xaa-Yaa-Gly) m , where the amino acid at one of the Yaa positions is substituted with a cysteine residue. Disulfide formation between the terminal thiol sulfur of the homocysteine residue of the first strand and the terminal thiol sulfur of the cysteine residue of the second strand reveals unstrained bridges that enhance the structure and substantially improve the stability of collagen triple helices as compared to other possible disulfide or thioether bridges. Thus, the disclosed collagen mimetic peptides have improved stability, and can be used to produce optimized collagen-like fibrillar assemblies for wound healing and other biomedical applications.