N-[(1Z,3E)-4-(3-methyl-1,3-benzothiazol-3-ium-2-yl)buta-1,3-dienyl]aniline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-[(1Z,3E)-4-(3-methyl-1,3-benzothiazol-3-ium-2-yl)buta-1,3-dienyl]aniline
• 化学式: C18H17N2S+
• 分子量: 293.4
• InChiKey: DKMANWQLBCVQRU-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  44.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS
  申请人：MAO FEI

  公开号：US20120115129A1

  公开（公告）日：2012-05-10

  Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

  本发明提供了酶底物及其相关技术。本发明的酶底物可以包括生物学功能荧光染料和酶特异性底物基团，以一种降低功能染料功能的方式连接。酶催化反应可以从酶底物中至少裂解一部分底物基团，以提供更具功能的产物染料。这种产物染料通常是非荧光或弱荧光的，在特定条件下，如与伴侣生物分子或伴侣生物分子组装结合时，相对荧光。因此，本发明的酶底物可以用于荧光检测，以及各种有用的应用，如在无细胞体系或活细胞中检测酶活性，筛选药物或诊断疾病。
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