7,8,9,10-tetrahydro-pyrido[2,1-a]isoindole | 108539-96-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 7,8,9,10-tetrahydro-pyrido[2,1-a]isoindole
• 英文别名: 7,8,9,10-Tetrahydro-pyrido[2,1-a]isoindol；7,8,9,10-Tetrahydropyrido[2,1-a]isoindole
• CAS: 108539-96-4
• 化学式: C₁₂H₁₃N
• 分子量: 171.242
• InChiKey: ACYVXHNDKNABRG-UHFFFAOYSA-N

物化性质

• 熔点：
  59-60 °C
• 密度：
  1.13±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  4.4
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 7,8,9,10-tetrahydro-pyrido[2,1-a]isoindole
  参考文献：
  名称：

  63.氨基烷基叔甲醇和衍生产品。第八部分 一些1-烷基和1：2-环烷吡咯啉

  摘要：

  DOI：

  10.1039/jr9580000338

文献信息

• A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane
  作者：Liusheng Zhu、Marc Vimolratana、Sean P. Brown、Julio C. Medina

  DOI：10.1016/j.tetlet.2008.01.067

  日期：2008.3

  A mild and convenient synthesis of substituted indolizines from readily available 2-(pyridin-2-yl)acetyl derivatives using (trimethylsilyl)diazomethane is described. The extension of this methodology to the synthesis of indole from 2-aminobenzaldehyde is also reported.

  描述了使用（三甲基甲硅烷基）重氮甲烷由容易获得的2-（吡啶-2-基）乙酰基衍生物温和方便地合成取代的吲哚嗪的方法。还报道了该方法的扩展到由2-氨基苯甲醛合成吲哚。
• TRICYCLIC COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
  申请人：Stearns Brian Andrew

  公开号：US20120004233A1

  公开（公告）日：2012-01-05

  Described herein are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD 2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.

  本文描述了PGD2受体拮抗剂。还描述了包括本文所述化合物的制药组合物和药物，以及使用这些PGD2受体拮抗剂的方法，单独或与其他化合物结合，用于治疗呼吸系统、心血管系统和其他PGD2依赖性或PGD2介导的疾病或病症。
• [EN] TRICYCLIC COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS<br/>[FR] COMPOSÉS TRICYCLIQUES EN TANT QU'ANTAGONISTES DES RÉCEPTEURS D2 DE LA PROSTAGLANDINE
  申请人：AMIRA PHARMACEUTICALS INC

  公开号：WO2010085820A2

  公开（公告）日：2010-07-29

  Described herein are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
• 63. Aminoalkyl tertiary carbinols and derived products. Part VIII. Some 1-alkyl- and 1 : 2-cycloalkano-pyrrocolines
  作者：P. A. Barrett、K. A. Chambers

  DOI：10.1039/jr9580000338

  日期：——