6-羟基-3-氧杂蒽-3-酮 | 60025-94-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 6-羟基-3-氧杂蒽-3-酮
• 英文名称: 6-Hydroxy-3H-xanthen-3-one
• 英文别名: 6-hydroxy-3-fluorone；resorufin；3-Hydroxy-6-oxo-dehydroxanthen；3-Hydroxy-6-oxo-9-dehydro-xanthen；6-hydroxy-xanthen-3-one；6-Hydroxy-xanthen-3-on；3H-xanthen-6-ol-3-one；6-Hydroxy-3-xanthen-3-one；6-hydroxyxanthen-3-one
• CAS: 60025-94-7
• 化学式: C₁₃H₈O₃
• 分子量: 212.205
• InChiKey: HXYAESYPQJYEBJ-UHFFFAOYSA-N

物化性质

• 沸点：
  520.1±50.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  6-羟基-3-氧杂蒽-3-酮 生成 氧杂蒽
  参考文献：
  名称：

  Moehlau; Koch, Chemische Berichte, 1894, vol. 27, p. 2888

  摘要：

  DOI：
• 作为产物：
  描述：

  9H-氧杂蒽-3,6-二醇 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以90%的产率得到6-羟基-3-氧杂蒽-3-酮
  参考文献：
  名称：

  Xanthenes: fluorone derivatives. 1

  摘要：

  Several new fluorone derivatives including 2,4,5,7-tetraiodo-6-hydroxy-3-fluorone, 2,4,5,7-tetrabromo-6-hydroxy-3-fluorone, and 2,4-diiodo-6-methoxy-3-fluorone were synthesized and their spectral and photophysical properties investigated.

  DOI：

  10.1021/jo00042a020

文献信息

• [EN] COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES<br/>[FR] COMPOSÉS ET PROCÉDÉS DE CONJUGAISON DE BIOMOLÉCULES
  申请人：LIFE TECHNOLOGIES CORP

  公开号：WO2012121973A1

  公开（公告）日：2012-09-13

  Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations are also provided.

  低铜点击化学，1,3-双极环加成和施陀林反应用于修饰生物分子。涉及低铜点击化学，1,3-双极环加成和施陀林反应的组合物、方法和试剂盒也提供。
• Crown ether derivatives
  申请人：Molecular Probes, Inc.

  公开号：US20020164616A1

  公开（公告）日：2002-11-07

  The invention describes crown ether chelators, including crown ethers having the formula 1 and aza-substituted and thia-substituted analogs thereof. These crown ethers are substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof. Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na + and K + ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.

  这项发明描述了冠醚螯合剂，包括具有公式1的冠醚和其氮杂基和硫杂基的类似物。这些冠醚被染料基团、化学反应基团、共轭物质或其组合所取代。特别有用的是被荧光染料取代的螯合剂，作为金属阳离子，特别是Na+和K+离子的指示剂，特别是当目标离子的结合导致指示剂的荧光性质发生变化，并且可以与离子浓度相关联。提供了利用螯合剂上的反应基团与染料、脂质和聚合物结合的方法，以及增强指示剂进入活细胞的方法。
• Competitive immunoassay
  申请人：Beechem Joseph

  公开号：US20060160068A1

  公开（公告）日：2006-07-20

  The present invention provides ligand-detection reagents, ligand analogs and methods for determining the presence of a ligand in a sample. The ligand-detection reagent comprises a ligand-binding antibody and a ligand analog to form an antibody-ligand analog complex wherein the ligand analog is covalently bonded to a reporter molecule. This complex may additionally comprise a labeling protein non-covalently bonded to the antibody to form a ternary complex wherein the labeling protein comprises a monovalent antibody fragment or a non-antibody protein that is covalently bonded to a label moiety. The reporter molecule is either quenched by the ligand-binding antibody or by the label moiety of the labeling protein, depending on the reporter molecule and the ligand-binding antibody, wherein the amount of quenching is directly related to the amount of ligand present in the sample. Alternatively, the ligand analog is fluorogenic wherein the ligand analog is essentially non-fluorescent in solution but when bound by the ligand-binding antibody the detectable signal increases. In this instance a decrease in signal, as opposed to the relieving of quenching, is measured for the presence of a target ligand.

  本发明提供了配体检测试剂、配体类似物和用于确定样品中配体存在的方法。该配体检测试剂包括一个配体结合抗体和一个配体类似物，形成一个抗体-配体类似物复合物，其中配体类似物与一个报告分子共价结合。该复合物还可以包括一个标记蛋白，非共价结合于抗体上，形成一个三元复合物，其中标记蛋白包括单价抗体片段或共价结合于标记基团的非抗体蛋白。报告分子可以被配体结合抗体或标记蛋白的标记基团熄灭，具体取决于报告分子和配体结合抗体，其中熄灭的程度与样品中配体的数量直接相关。或者，配体类似物是荧光原性的，其中配体类似物在溶液中基本上不发荧光，但当被配体结合抗体结合时，可检测的信号增加。在这种情况下，对于目标配体的存在，测量的是信号的降低，而不是熄灭的缓解。
• Phosphonylated fluorescent dyes and conjugates
  申请人：Lukhtanov Eugeny

  公开号：US20060199955A1

  公开（公告）日：2006-09-07

  Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.

  提供试剂用于将膦酸酯基团引入荧光染料中。同时，还提供了制备染料偶联物的方法。
• LABELING AND DETECTION OF NUCLEIC ACIDS
  申请人：AGNEW Brian

  公开号：US20080050731A1

  公开（公告）日：2008-02-28

  Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling nucleic acids with an azide group.

  在某些实施例中，提供了形成带有报告分子、载体分子或固体支持的偶氮修饰核酸共轭物的新方法。在其他实施例中，提供了用偶氮基团酶标记核酸的方法。