N,N'-dicyclohexylquinazoline-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N,N'-dicyclohexylquinazoline-2,4-diamine
• 英文别名: 2-N,4-N-dicyclohexylquinazoline-2,4-diamine
• 化学式: C₂₀H₂₈N₄
• 分子量: 324.5
• InChiKey: NZIIGEHBRMKNAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  49.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS AND METHODS FOR PREVENTING, TREATING, OR AMELIORATING AIRWAY DISEASE<br/>[FR] COMPOSÉS ET MÉTHODES POUR PRÉVENIR, TRAITER OU AMÉLIORER UNE MALADIE DES VOIES RESPIRATOIRES
  申请人：[en]THOMAS JEFFERSON UNIVERSITY

  公开号：WO2022173743A1

  公开（公告）日：2022-08-18

  The β2-adrenergic receptor (β2AR) is a primary target in the treatment of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Since β-agonist treatment of airway disease can have severe side effects, compounds that attenuate the side effects of β-agonists have been identified via their ability to inhibit β2AR interaction with β-arrestins. These compounds are specific for the β2AR and effectively protect against the desensitization observed with β-agonist treatment in model cells and airway tissue. The present disclosure provides compounds and methods for treating airway disease, such as but not limited to COPD and/or asthma.