N-(5,6-dihydrobenzo[h]quinazolin-2-yl)thiophene-2-carboxamde | 306979-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(5,6-dihydrobenzo[h]quinazolin-2-yl)thiophene-2-carboxamde
• 英文别名: N-(5,6-dihydrobenzo[h]quinazolin-2-yl)-2-thiophenecarboxamide；N-(5,6-dihydrobenzo[h]quinazolin-2-yl)thiophene-2-carboxamide
• CAS: 306979-39-5
• 化学式: C₁₇H₁₃N₃OS
• 分子量: 307.376
• InChiKey: KIWRFBMYXOFTFQ-UHFFFAOYSA-N

物化性质

• 密度：
  1.391±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Antistress drug and medical use thereof
  申请人：Ohmoto Kazuyuki

  公开号：US20070099938A1

  公开（公告）日：2007-05-03

  The compound represented by formula (I) (wherein ringA is cyclic group which may have a substituent(s), Q is alkyl which may have a substituent(s) or cyclic ring which may have a substituent(s), ringD is cyclic ring which may have a substituent(s), W is a single bond or a spacer of which main chain has an atom number of 1-4, Y is a spacer of which main chain has an atom number of 1-4.), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof Since the compounds represented by formula (I), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof have the affinity to MBR, they are useful for the prevention and/or treatment for disease caused by stress.

  化合物的分子式为（I）（其中环A是一个可以有取代基的环状基团，Q是一个可以有取代基或环状基团的烷基，环D是一个可以有取代基的环状基团，W是一个单键或具有1-4个原子数的主链的间隔键，Y是具有1-4个原子数的主链的间隔键），其盐，N-氧化物或溶剂化物，或其前药。由于分子式（I）所代表的化合物，其盐，N-氧化物或溶剂化物，或其前药具有对MBR的亲和力，因此它们对于预防和/或治疗由压力引起的疾病是有用的。
• COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Jimenez Juan-Miguel

  公开号：US20100280026A1

  公开（公告）日：2010-11-04

  The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.

  本发明涉及作为蛋白激酶抑制剂有用的化合物。该发明还提供了制备这些化合物的方法，包括这些化合物的药学上可接受的组合物，以及使用这些化合物和组合物治疗各种疾病、状况或障碍的方法。
• ANTISTRESS DRUG AND MEDICAL USE THEREOF
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1679309A1

  公开（公告）日：2006-07-12

  The compound represented by formula (I) (wherein ringA is cyclic group which may have a substituent(s), Q is alkyl which may have a substituent(s) or cyclic ring which may have a substituent(s), ringD is cyclic ring which may have a substituent(s), W is a single bond or a spacer of which main chain has an atom number of 1-4, Y is a spacer of which main chain has an atom number of 1-4.), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof Since the compounds represented by formula (I), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof have the affinity to MBR, they are useful for the prevention and/or treatment for disease caused by stress.

  式 (I) 所代表的化合物 (其中，环 A 为可带取代基的环状基团，Q 为可带取代基的烷基或可带取代基的环状环，环 D 为可带取代基的环状环，W 为单键或主链原子序数为 1-4 的间隔键，Y 为主链原子序数为 1-4 的间隔键)、其盐、其 N-氧化物或其溶液或其原药。由于式 (I) 所代表的化合物、其盐、其 N-氧化物或其溶解物或其原药具有与 MBR 的亲和力，因此可用于预防和/或治疗由压力引起的疾病。
• US7700609B2
  申请人：——

  公开号：US7700609B2

  公开（公告）日：2010-04-20
• US8017619B2
  申请人：——

  公开号：US8017619B2

  公开（公告）日：2011-09-13