8-Hydroxydigitoxigenin

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 8-Hydroxydigitoxigenin
• 英文别名: 3-[(3S,5R,8S,9R,10S,13R,14R,17R)-3,8,14-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
• 化学式: C₂₃H₃₄O₅
• 分子量: 390.5
• InChiKey: DLJAGQZQTFSTKM-BGKNSHFJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Method and compostitions for treating coronavirus infection
  申请人：PHOENIX BIOTECHNOLOGY, INC.

  公开号：US10729735B1

  公开（公告）日：2020-08-04

  A method of treating viral infection, such as viral infection caused by a virus of the Coronaviridae family, is provided. A composition having at least oleandrin is used to treat viral infection.

  提供了一种治疗病毒感染的方法，例如由冠状病毒科病毒引起的病毒感染。一种至少含有齐墩果素的组合物用于治疗病毒感染。
• NATURAL COMPOUNDS AND FIBROSIS
  申请人：MEDIZINISCHE HOCHSCHULE HANNOVER (MHH)

  公开号：US20190350923A1

  公开（公告）日：2019-11-21

  The present invention relates to an inhibitor of miR-671-5p for use in a method of preventing or treating fibrosis. Further, the present invention encompasses a kit comprising said inhibitor of miR-671-5p. The present invention also relates to an in vitro method for identifying a compound for preventing or treating fibrosis.
• Method and Compositions for Treating Coronavirus Infection
  申请人：PHOENIX BIOTECHNOLOGY, INC.

  公开号：US20220054521A1

  公开（公告）日：2022-02-24

  A method of treating viral infection, such as viral infection caused by a virus of the Coronaviridae family, is provided. A composition having at least oleandrin is used to treat viral infection.
• [EN] METHOD AND COMPOSITIONS FOR TREATING GLIOBLASTOMA<br/>[FR] MÉTHODE ET COMPOSITIONS DE TRAITEMENT D'UN GLIOBLASTOME
  申请人：PHOENIX BIOTECHNOLOGY INC

  公开号：WO2021113027A1

  公开（公告）日：2021-06-10

  A method of treaing glioma is provided. A combination protocol as described herein includes radiotherapy, chemotherapy, and pharmacotherapy. Resection of the glioma is optionally included in the combination protocol. Pharmacotherapy is conducted with an oleandrin-containing composition. Treatment of glioblastoma is particularly contemplated.
• [EN] EXTRACT CONTAINING OLEANDRIN AND METHOD OF PRODUCTION THEREOF<br/>[FR] EXTRAIT CONTENANT DE L'OLÉANDRINE ET SON PROCÉDÉ DE PRODUCTION
  申请人：PHOENIX BIOTECHNOLOGY INC

  公开号：WO2021242590A1

  公开（公告）日：2021-12-02

  A subcritical liquid extraction process for the production of oleandrin or oleandrin- containing extract is provided. The process provides improvements over other methods of preparing oleandrin-containing extract. The extract, pharmaceutical compositions, dosage forms and nutraceutical compositions comprising oleandrin or said extract are provided. Methods of treating diseases, disorders or conditions that are therapeutically responsive to oleandrin are also provided.