2-Cyano-N-(6,7-dimethoxyquinazolin-4-yl)benzenesulphonamide | 364038-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-Cyano-N-(6,7-dimethoxyquinazolin-4-yl)benzenesulphonamide
• 英文别名: 2-cyano-N-(6,7-dimethoxyquinazolin-4-yl)benzenesulfonamide
• CAS: 364038-79-9
• 化学式: C₁₇H₁₄N₄O₄S
• 分子量: 370.389
• InChiKey: UWNDYFDBGROSEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-氯-6,7-二甲氧基喹唑啉 生成 2-Cyano-N-(6,7-dimethoxyquinazolin-4-yl)benzenesulphonamide
  参考文献：
  名称：

  Bicyclic amine derivatives as inhibitors of class 1 receptor tyrosine kinases

  摘要：

  公式（1）中描述了Ar为芳基或杂芳基基团；Y为—S(O2)—或—C(O)—基团；R1为氢原子或卤素原子或烷基、卤代烷基、烷氧基、卤代烷氧基或氰基；X为氮原子或C(R1a)基团，其中R1a如R1所定义，可以相同也可以不同；W和Z各自为碳原子，并与U一起形成一个可选择取代的五元或六元单环芳香或杂芳基团；以及它们的盐、溶剂合物、水合物和N-氧化物。这些化合物能够抑制I类受体酪氨酸激酶的活性，并可用于预防和治疗癌症、银屑病、再狭窄、动脉粥样硬化和纤维化等过度增殖性疾病。

  公开号：

  US20030153755A1

文献信息

• BICYCLIC AMINE DERIVATIVES AS INHIBITORS OF CLASS 1 RECEPTOR TYROSINE KINASES
  申请人：Celltech Chiroscience Limited

  公开号：EP1268448A1

  公开（公告）日：2003-01-02
• US7012076B2
  申请人：——

  公开号：US7012076B2

  公开（公告）日：2006-03-14
• [EN] BICYCLIC AMINE DERIVATIVES AS INHIBITORS OF CLASS 1 RECEPTOR TYROSINE KINASES<br/>[FR] DERIVES D'AMINE BICYCLIQUE UTILISES COMME INHIBITEURS DES TYROSINES KINASES RECEPTRICES DE CLASSE 1
  申请人：CELLTECH CHIROSCIENCE LTD

  公开号：WO2001072720A1

  公开（公告）日：2001-10-04

  Fused bicyclic amines of formula (1) are described wherein Ar is an aryl or heteroaryl group; Y is a -S(O2)- or -C(O)- group; R1 is a hydrogen or halogen atom or an alkyl, haloalkyl, alkoxy, haloalkoxy or cyano group; X is a nitrogen atom or a C(R1a) group where R1a is as defined for R1 and may be the same or different; W and Z are each a carbon atom and together with U form an optionally substituted five- or six-membered monocyclic aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the activity of Class 1 receptor tyrosine kinases and are of use in the prophylaxis and treatment of hyperproliferative disorders such as cancer, psoriasis, restenosis, atherosclerosis and fibrosis.
• Bicyclic amine derivatives as inhibitors of class 1 receptor tyrosine kinases
  申请人：——

  公开号：US20030153755A1

  公开（公告）日：2003-08-14

  Fused bicyclic amines of formula (1) are described wherein Ar is an aryl or heteroaryl group; Y is a —S(O 2 )— or —C(O)— group; R 1 is a hydrogen or halogen atom or an alkyl, haloalkyl, alkoxy, haloalkoxy or cyano group; X is a nitrogen atom or a C(R 1a ) group where R 1a is as defined for R 1 and may be the same or different; W and Z are each a carbon atom and together with U form an optionally substituted five- or six-membered monocyclic aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the activity of Class I receptor tyrosine kinases and are of use in the prophylaxis and treatment of hyperproliferative disorders such as cancer, psoriasis, restenosis, atherosclerosis and fibrosis.

  公式（1）中描述了Ar为芳基或杂芳基基团；Y为—S(O2)—或—C(O)—基团；R1为氢原子或卤素原子或烷基、卤代烷基、烷氧基、卤代烷氧基或氰基；X为氮原子或C(R1a)基团，其中R1a如R1所定义，可以相同也可以不同；W和Z各自为碳原子，并与U一起形成一个可选择取代的五元或六元单环芳香或杂芳基团；以及它们的盐、溶剂合物、水合物和N-氧化物。这些化合物能够抑制I类受体酪氨酸激酶的活性，并可用于预防和治疗癌症、银屑病、再狭窄、动脉粥样硬化和纤维化等过度增殖性疾病。