2-(2,6-dichlorophenyl)-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one | 1375103-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(2,6-dichlorophenyl)-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one
• CAS: 1375103-54-0
• 化学式: C₂₀H₁₅Cl₂N₃O
• 分子量: 384.265
• InChiKey: RJSSBMRLVYXZGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.59
• 重原子数：
  26.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  44.37
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  2,6-二氯苯甲醛 、 2-amino-N'-phenylbenzohydrazide 在 aluminum oxide 、 柠檬酸 作用下， 反应 0.17h， 以86%的产率得到2-(2,6-dichlorophenyl)-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one
  参考文献：
  名称：

  Tandem synthesis of 2,3-dihydroquinazolin-4(1H)-ones on grinding under solvent-free conditions

  摘要：

  AbstractCitric acid promoted synthesis of a mini‐library 2,3‐dihydroquinazolin‐4(1H)‐ones with good to excellent yields is achieved by tandem reaction of anthranilamides (or anthranilhydrazides) with aldehydes on grinding at room temperature under solvent‐free conditions. This method has notable advantages in terms of simple workup, short reaction time, cost‐effective, and environmentally benign. J. Heterocyclic Chem., (2012).

  DOI：

  10.1002/jhet.759

文献信息

• Tandem synthesis of 2,3-dihydroquinazolin-4(1H)-ones on grinding under solvent-free conditions
  作者：Quan-Sheng Ding、Ji-Lei Zhang、Jiu-Xi Chen、Miao-Chang Liu、Jin-Chang Ding、Hua-Yue Wu

  DOI：10.1002/jhet.759

  日期：2012.3

  AbstractCitric acid promoted synthesis of a mini‐library 2,3‐dihydroquinazolin‐4(1H)‐ones with good to excellent yields is achieved by tandem reaction of anthranilamides (or anthranilhydrazides) with aldehydes on grinding at room temperature under solvent‐free conditions. This method has notable advantages in terms of simple workup, short reaction time, cost‐effective, and environmentally benign. J. Heterocyclic Chem., (2012).