4-N-methyleneaminophenol | 62627-89-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-N-methyleneaminophenol
• 英文别名: 4-(Methylideneamino)phenol
• CAS: 62627-89-8
• 化学式: C₇H₇NO
• 分子量: 121.139
• InChiKey: VVKFZFBGPIGOHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲醇 、 对氨基苯酚 在 titanium(IV) dioxide 作用下， 反应 20.0h， 以83%的产率得到4-N-methyleneaminophenol
  参考文献：
  名称：

  New approaches to photocatalytic reaction of low concentrations of arylamines in alcohols

  摘要：

  在存在锐钛矿型TiO2纳米粉末的情况下，研究了一系列芳香胺（例如1,4-苯二胺、1,2-苯二胺、4-氨基苯酚和2-氨基苯酚）在典型的初级醇中低浓度的光催化相互作用。GC–MS分析照射后的溶液显示，除了1,2-苯二胺外，芳香胺的10 mmol/L醇溶液主要生成了相应的亚胺。在这些条件下照射2-氨基苯酚，导致其氧化和二聚为2-氨基-3H-苯并噁唑-3-酮。

  DOI：

  10.1007/s11164-011-0472-y

文献信息

• (Hetero)Cyclycarboxamides for Controlling Pathogenic Fungi
  申请人：Gewehr Markus

  公开号：US20070275981A1

  公开（公告）日：2007-11-29

  The invention relates to the use of (hetero)cyclylcarboxamides of general formula (I) and to the agriculturally useful salts thereof for controlling plant pathogenic fungi, the variables in formula (I) having the following designations: A represents phenyl or an at least monosaturated five-membered or six-membered heterocycle with 1, 2 or 3 heteroatoms as ring members selected from N, O, S, S(═O) and S(═O) 2 , where phenyl and the at least monosaturated five-membered or six-membered heterocycle can be unsubstituted or substituted according to the description; Y represents oxygen or sulphur; R 1 represents H, OH, alkyl, cycloalkyl, alkoxy, halogenalkyl, halogencycloalkyl or halogenalkoxy; R 2 and R 3 represent H, halogen, nitro, CN, alkyl, cycloalkyl, alkenyl, alkinyl, alkoxy, halogenalkyl, halogencycloalkyl, halogenalkenyl, halogenalkinyl or halogenalkoxy; R 4 represents halogen, nitro, CN, alkyl, cycloalkyl, alkenyl, alkinyl, alkoxy, halogenalkyl, halogencycloalkyl, halogenalkenyl, halogenalkinyl or halogenalkoxy; R 5 represents hydrogen, halogen, nitro, CN, OH, alkyl, cycloalkyl, alkenyl, alkinyl, alkoxy, alkenyloxy, alkinyloxy, alkoxyalkoxy, halogenalkyl, halogencycloalkyl, halogenalkenyl, halogenalkinyl or halogenalkoxy; alklthio, halogenalkylthio, alkylsulfinyl, halogenalkylsulfinyl, alkylsulfonyl, halogenalkylsulfonyl, —(CR 6 )═NOR 7 , —C(O)R 8 , NR 9 R 10 , —C(O)NR 9 R 10 , —C(S)NR 9 R 10 , phenyl or phenylalkyl, the phenyl ring in the last two radicals optionally comprising between 1 and 4 of the radicals cited for R 4 ; R 6 , R 7 , R 8 , R 9 and R 10 have the designations cited in the description; the two radicals R 4 and R 5 bound to adjacent carbon atoms can also represent an alkylene chain with 3 to 5 members, wherein 1 or 2 non-adjacent CH 2 groups can also be replaced by O or S, and part or all of the hydrogens can be replaced by halogen; Ar represents phenyl, naphtyl or a five-membered or six-membered heteroaromatic radical with 1, 2 or 3 heteroatoms as ring members selected from N, O, and S, that can optionally also carry a fused benzene ring; and n represents 0, 1, 2, 3, or 4. The invention also relates to crop protection agents containing said compounds.

  该发明涉及使用一般式（I）的（杂）环戊酰胺及其在农业上有用的盐来控制植物病原真菌，式（I）中的变量具有以下符号：A代表苯或至少含有1、2或3个杂原子（N、O、S、S(═O)和S(═O)2）的五元环或六元环，其中苯和至少含有1个杂原子的五元环或六元环可以按照说明未取代或取代；Y代表氧或硫；R1代表H、OH、烷基、环烷基、烷氧基、卤代烷基、卤代环烷基或卤代烷氧基；R2和R3代表H、卤素、硝基、CN、烷基、环烷基、烯基、炔基、烷氧基、卤代烷基、卤代环烷基、卤代烯基、卤代炔基或卤代烷氧基；R4代表卤素、硝基、CN、烷基、环烷基、烯基、炔基、烷氧基、卤代烷基、卤代环烷基、卤代烯基、卤代炔基或卤代烷氧基；R5代表氢、卤素、硝基、CN、OH、烷基、环烷基、烯基、炔基、烷氧基、烯基氧基、炔基氧基、烷氧基烷氧基、卤代烷基、卤代环烷基、卤代烯基、卤代炔基或卤代烷氧基；alklthio、卤代烷硫基、烷基磺酰基、卤代烷磺酰基、烷基磺酰基、卤代烷磺酰基、—(CR6)═NOR7、—C(O)R8、NR9R10、—C(O)NR9R10、—C(S)NR9R10、苯或苯基烷基，最后两个基团中的苯环可以选择包含1到4个R4中列出的基团；R6、R7、R8、R9和R10具有说明中列出的符号；相邻碳原子上结合的两个基团R4和R5也可以代表具有3到5个成员的烷基链，其中1或2个非相邻的CH2基团也可以被O或S替换，部分或全部氢原子可以被卤素取代；Ar代表苯、萘或具有1、2或3个杂原子（N、O和S）的五元环或六元环杂芳基，也可以携带一个融合的苯环；n代表0、1、2、3或4。该发明还涉及含有上述化合物的作物保护剂。
• 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases
  申请人：Fink Anne Cynthia

  公开号：US20070060582A1

  公开（公告）日：2007-03-15

  This invention relates to compounds of the formula (I) wherein the variable substituents are described herein. The compounds are useful for the treatment of conditions and diseases characterized by an aberrant MAP kinase signaling pathway, such as cancer.

  本发明涉及公式（I）中变量取代基的化合物，所述的化合物可用于治疗由异常MAP激酶信号通路引起的疾病和症状，例如癌症。
• RAPAMYCIN ANALOGS AS ANTI-CANCER AGENTS
  申请人：Sun Connie L.

  公开号：US20110098241A1

  公开（公告）日：2011-04-28

  Analogs and derivatives of rapamycin are provided, wherein the analogs and derivatives can bind to FK-506 binding protein (FKBP), or inhibit the mTOR function of an FKBP, or both. The analogs and derivatives are rapamycin include the rapamycin skeleton substituted at the 42-hydroxyl group with certain specified chemically feasible groups. Methods of using the rapamycin analogs and derivatives in treatment of malconditions such as cancer, and methods of synthesizing the rapamycin analogs and derivatives, are provided.

  本文提供了雷帕霉素的类似物和衍生物，其中这些类似物和衍生物可以与FK-506结合蛋白（FKBP）结合，或抑制FKBP的mTOR功能，或两者兼备。这些雷帕霉素的类似物和衍生物包括在42-羟基基团上用某些特定的化学可行基团替代的雷帕霉素骨架。本文还提供了使用这些雷帕霉素类似物和衍生物治疗癌症等疾病的方法以及合成这些雷帕霉素类似物和衍生物的方法。
• Second harmonic generation with schiff bases
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0235955A2

  公开（公告）日：1987-09-09

  This invention is concerned with materials for nonlinear optical devices for the conversion of optical energy at one frequency to optical energy at another frequency. Laser techniques have been developed to a great extent and it is possible to obtain various kinds of laser light by utilizing solid, gas, and liquid media. Laser light having various wavelengths is often desired and in some cases, a laser light exhibiting a continuous spectrum over a certain range of wavelengths is desired. One means for converting coherent laser light of a fundamental frequency into laser light of a wavelength having a frequency twice the fundamental frequency (i. e., the second harmonic) involves passing the laser light through a nonlinear optical crystal. This invention involves devices for and method of generating coherent second harmonic light radiation. The devices comprise a laser source of coherent light radiation at a fixed fundamental frequency, a Schiff base compound, means for directing the output radiation of the laser onto the Schiff base compound, and output means for utilizing the second harmonic frequency. Preferably, one moiety of the Schiff base compound has a hyperpolarizable group and the other moiety of the Schiff base compound has a configuration so that the compound crystallizes in a non-centrosymmetric configuration.

  本发明涉及将一种频率的光能转换为另一种频率的光能的非线性光学设备材料。 激光技术已经得到了长足的发展，利用固体、气体和液体介质可以获得各种激光。人们通常需要各种波长的激光，在某些情况下，还需要在一定波长范围内显示连续光谱的激光。将基频的相干激光转换成频率为基频两倍（即二次谐波）的波长激光的一种方法是将激光穿过非线性光学晶体。 本发明涉及产生相干二次谐波光辐射的装置和方法。这些装置包括一个固定基频相干光辐射激光源、一个席夫碱化合物、将激光输出辐射引导到席夫碱化合物上的装置，以及利用二次谐波频率的输出装置。最好是希夫碱化合物的一个分子具有超极化基团，而希夫碱化合物的另一个分子具有使该化合物以非中心对称构型结晶的构型。
• POLYSUBSTITUTED PYRIDINE COMPOUND, PREPARATION METHOD, USE AND PHARMACEUTICAL COMPOSITION
  申请人：Peking University Founder Group Co., Ltd

  公开号：EP3130588A1

  公开（公告）日：2017-02-15

  The present invention provides a polysubstituted pyridine compound of Formula I, a preparation method, a use and a pharmaceutical composition thereof. The polysubstituted pyridine compound of Formula I according to the present invention has an excellent anti-tumor effect, can inhibit various cell kinases simultaneously, has significantly excellent pharmacokinetic characteristics, and is very suitable for oral and intravenous administration. The pharmaceutical composition according to the present invention can be useful for treating tumors and cancers.

  本发明提供了一种式I的多取代吡啶化合物及其制备方法、用途和药物组合物。根据本发明的式 I 的多取代吡啶化合物具有优异的抗肿瘤效果，可同时抑制多种细胞激酶，具有显著优异的药代动力学特征，非常适合口服和静脉注射。根据本发明的药物组合物可用于治疗肿瘤和癌症。