N-(1,3,4-Thiadiazol-2-yl)pivalamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(1,3,4-Thiadiazol-2-yl)pivalamide
• 英文别名: 2,2-dimethyl-N-(1,3,4-thiadiazol-2-yl)propanamide
• 化学式: C₇H₁₁N₃OS
• mdl: MFCD00500788
• 分子量: 185.25
• InChiKey: WCZMAJPTDZWGFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 5-Quinoline derivatives having an anti-bacterial activity
  申请人：Dale Glenn

  公开号：US20100324030A1

  公开（公告）日：2010-12-23

  The present invention describes novel anti-bacterial compounds of the formula (I). These compounds are, amongst others, of interest as inhibitors of DNA gyrase and topoisomerases, for example of topoisomerase II and IV.

  本发明描述了通式(I)的新型抗菌化合物。这些化合物,除其他外,作为DNA促旋酶和拓扑异构酶的抑制剂,例如拓扑异构酶II和IV,具有研究价值。
• Novel Compounds Having an Anti-Bacterial Activity
  申请人：Pierau Sabine

  公开号：US20070244103A1

  公开（公告）日：2007-10-18

  The present invention describes novel anti-bacterial compounds of formula (I). Q-A-R 3 (I) These compounds are, amongst others, of interest as inhibitors of DNA gyrase.

  本发明描述了式(I)的新型抗菌化合物。Q-A-R3(I)这些化合物是DNA旋转酶抑制剂等方面的有趣化合物。
• TETRACYCLIC COMPOUND
  申请人：Yamamoto Junichiro

  公开号：US20110112299A1

  公开（公告）日：2011-05-12

  Provided are a tetracyclic compound represented by the formula (I): [in the formula (I), the formula (A) represents a benzene ring or the like, X represents CH or a nitrogen atom, Q represents —O— or the like, R 1 , R 2 , and R 3 may be the same or different and each represent a hydrogen atom or the like, l, m, and n each represent an integer from one to the maximum substitutable number of substituents, and R 4 and R 5 may be the same or different and each represent a hydrogen atom or the like], or a pharmaceutically acceptable salt thereof, and the like.

  提供的是一个四环化合物，其化学式表示为(I)：[在化学式(I)中，式(A)表示苯环或类似物，X表示CH或氮原子，Q表示-O-或类似物，R1、R2和R3可以相同也可以不同，每个都表示氢原子或类似物，l、m和n每个表示从1到可替代取代基的最大数的整数，R4和R5可以相同也可以不同，每个都表示氢原子或类似物]，或其药学上可接受的盐等。
• Inhibitors of N-linked glycosylation and methods using same
  申请人：YALE UNIVERSITY

  公开号：US11219625B2

  公开（公告）日：2022-01-11

  The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need thereof. The methods comprise administering to the subject an effective amount of at least one compound of the invention.

  本发明包括用于预防或治疗有需要的受试者与N-连接糖基化相关的疾病的新型化合物和方法。这些方法包括向受试者施用有效量的至少一种本发明化合物。
• Inhibitors of N-Linked Glycosylation and Methods Using Same
  申请人：YALE UNIVERSITY

  公开号：US20190000858A1

  公开（公告）日：2019-01-03

  The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need thereof. The methods comprise administering to the subject an effective amount of at least one compound of the invention.