(3aS,6aS)-4-(7,8-dimethoxyquinazolin-4-yl)hexahydro-2H-furo[3,2-b]pyrrole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (3aS,6aS)-4-(7,8-dimethoxyquinazolin-4-yl)hexahydro-2H-furo[3,2-b]pyrrole
• 英文别名: (3aS,6aS)-4-(7,8-dimethoxyquinazolin-4-yl)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]pyrrole
• 化学式: C₁₆H₁₉N₃O₃
• 分子量: 301.345
• InChiKey: IGKWVEWYKGNGIZ-RYUDHWBXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  56.7
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• HEXAHYDROFUROPYRROLES AS PDE1 INHIBITORS
  申请人：H. Lundbeck A/S

  公开号：EP3102584B1

  公开（公告）日：2019-01-16
• Hexahydrofuropyrroles as PDE1 Inhibitors
  申请人：H. LUNDBECK A/S

  公开号：US20160347759A1

  公开（公告）日：2016-12-01

  The present invention provides hexahydrofuropyrroles as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.
• US9718832B2
  申请人：——

  公开号：US9718832B2

  公开（公告）日：2017-08-01
• [EN] HEXAHYDROFUROPYRROLES AS PDE1 INHIBITORS<br/>[FR] HEXAHYDROFUROPYRROLES UTILISÉS COMME INHIBITEURS DE PDE1
  申请人：LUNDBECK & CO AS H

  公开号：WO2015118097A1

  公开（公告）日：2015-08-13

  The present invention provides hexahydrofuropyrroles as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.