D,L-4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione dioxime | 134316-48-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: D,L-4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione dioxime
• 英文别名: 3,6,6,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime；N,N'-[(2,2-Dimethylpropane-1,3-diyl)bis(azanediylbut-3-yl-2-ylidene)]dihydroxylamine；N-[3-[[3-(3-hydroxyiminobutan-2-ylamino)-2,2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine
• CAS: 134316-48-6
• 化学式: C₁₃H₂₈N₄O₂
• 分子量: 272.391
• InChiKey: BPNZYADGDZPRTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  89.2
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,6,6,9-四甲基-4,8-二氮杂-3,8-十一碳二烯-2,10-二酮二肟 以30%的产率得到D,L-4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione dioxime
  参考文献：
  名称：

  Assessment of radiation-induced DNA damage caused by the incorporation of -radiopharmaceuticals in murine lymphocytes using single cell gel electrophoresis

  摘要：

  The DNA damage induced by the Tc-99m-radiopharmaceuticals incorporation to the cell was determined by the single-cell gel electrophoresis in murine lymphocytes in vitro. The Tc-99m-hexamethyl-propylene amine oxime (Tc-99m-HMPAO) and Tc-99m-2,5-dihydroxybenzoic acid (Tc-99m-gentisic acid) induced nearly 100% of cells with breaks and/or alkali labile sites, which is explained by the action of the Auger electrons produced by the decay of the Tc-99m. These results agree with the doses of 1.6 and 1.0 Gy estimated by subcellular dosimetry for Tc-99m-HMPAO that is incorporated in the cytoplasm, and the Tc-99m-gentisic acid, which remains bonded to the cell membrane, respectively. The results imply that Auger electrons are able to cause important DNA damage, when the radionuclide is incorporated in the range of a few microns from the nuclei. (C) 2000 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s1383-5718(99)00221-1

文献信息

• Radiopharmaceutical bacteriostats
  申请人：MERCK FROSST CANADA INC.

  公开号：EP0508724A1

  公开（公告）日：1992-10-14

  Benzalkonium chloride and benzethonium chloride are each useful in radiopharmaceutical preparations (optionally in the presence of a polymyxin or a polymyxin derivative) as bacteriostatic agents which are compatible with anti-oxidants.

  苯扎氯铵和苄索氯铵在放射性药物制剂中（可选择在多粘菌素或多粘菌素衍生物存在的情况下）均可用作与抗氧化剂兼容的抑菌剂。
• US5093105A
  申请人：——

  公开号：US5093105A

  公开（公告）日：1992-03-03
• US5227152A
  申请人：——

  公开号：US5227152A

  公开（公告）日：1993-07-13
• US5306482A
  申请人：——

  公开号：US5306482A

  公开（公告）日：1994-04-26
• Assessment of radiation-induced DNA damage caused by the incorporation of -radiopharmaceuticals in murine lymphocytes using single cell gel electrophoresis
  作者：Martha Pedraza-López、Guillermina Ferro-Flores、Ma.Teresa Mendiola-Cruz、Pedro Morales-Ramı́rez

  DOI：10.1016/s1383-5718(99)00221-1

  日期：2000.2

  The DNA damage induced by the Tc-99m-radiopharmaceuticals incorporation to the cell was determined by the single-cell gel electrophoresis in murine lymphocytes in vitro. The Tc-99m-hexamethyl-propylene amine oxime (Tc-99m-HMPAO) and Tc-99m-2,5-dihydroxybenzoic acid (Tc-99m-gentisic acid) induced nearly 100% of cells with breaks and/or alkali labile sites, which is explained by the action of the Auger electrons produced by the decay of the Tc-99m. These results agree with the doses of 1.6 and 1.0 Gy estimated by subcellular dosimetry for Tc-99m-HMPAO that is incorporated in the cytoplasm, and the Tc-99m-gentisic acid, which remains bonded to the cell membrane, respectively. The results imply that Auger electrons are able to cause important DNA damage, when the radionuclide is incorporated in the range of a few microns from the nuclei. (C) 2000 Elsevier Science B.V. All rights reserved.