2-[[4-benzyl-5-[1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[[4-benzyl-5-[1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]acetamide
• 化学式: C₂₅H₂₇FN₆OS₂
• 分子量: 510.7
• InChiKey: LEYDRTNITHMRJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Inhibitors Of Protein Phosphatase-1 And Uses Thereof
  申请人：Nekhai Sergei

  公开号：US20090264463A1

  公开（公告）日：2009-10-22

  Inhibitors of Protein Phosphatase-1 have been shown to slow replication of HIV-1. Inhibitors of PP 1 and their use for treatment or prevention of HIV-1 infections are disclosed.
• Inhibitors of Protein Phosphatase-1 and Uses Thereof
  申请人：HOWARD UNIVERSITY

  公开号：US20160024013A1

  公开（公告）日：2016-01-28

  Inhibitors of protein phosphatase-1 (PP-1) and their use in a method for the treatment or prevention of viral infections caused by HIV or ebola virus are disclosed. Inhibitors of protein phosphatase-1 in effective amounts have been shown to slow down viral replication upon contacting ebola virus or cells containing the ebola virus.
• US8278326B2
  申请人：——

  公开号：US8278326B2

  公开（公告）日：2012-10-02
• US9447047B2
  申请人：——

  公开号：US9447047B2

  公开（公告）日：2016-09-20