3-Butoxy-2-methylquinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-Butoxy-2-methylquinazolin-4-one
• 化学式: C₁₃H₁₆N₂O₂
• 分子量: 232.28
• InChiKey: ZHGQDBHEEDRKSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS
  申请人：Albericio Fernando

  公开号：US20100144588A1

  公开（公告）日：2010-06-10

  Novel iminium-type coupling agents containing proton acceptors in their iminium moiety, which can be used beneficially as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization suppressing coupling agents for use in peptide syntheses, are disclosed. Further disclosed are a process of preparing such iminium-type coupling agents and their use in the preparation of polypeptides and/or polynucleotides.

  包含质子受体的新型亚胺型偶联剂，可有益地用作各种化学多肽和/或多核苷酸合成中的偶联剂，并且特别适用于在肽合成中提高产率和抑制旋光异构化的偶联剂。还公开了一种制备这种亚胺型偶联剂的方法以及它们在多肽和/或多核苷酸制备中的用途。
• [EN] PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS<br/>[FR] AGENTS DE COUPLAGE DE TYPE IMINIUM/CARBOCATION ACCEPTEURS DE PROTONS COUPLING AGENTS
  申请人：LUXEMBOURG BIOTECHNOLOGIES LTD

  公开号：WO2008139481A2

  公开（公告）日：2008-11-20

  [EN] Novel iminium-type coupling agents containing proton acceptors in their iminium moiety, which can be used beneficially as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization suppressing coupling agents for use in peptide syntheses, are disclosed. Further disclosed are a process of preparing such iminium-type coupling agents and their use in the preparation of polypeptides and/or polynucleotides.
  [FR] L'invention porte sur de nouveaux agents de couplage de type iminium contenant des accepteurs de protons dans leur fraction iminium, qui peuvent être utilisés de façon utile comme agents de couplage dans diverses synthèses chimiques de polypeptides et/ou de polynucléotides, et sont particulièrement utiles comme agents de couplage améliorant le rendement et supprimant la racémisation pour une utilisation dans des synthèses peptidiques. L'invention porte en outre sur un procédé de préparation de tels agents de couplage de type iminium et sur leur utilisation dans la préparation de polypeptides et/ou polynucléotides.
• [EN] COUPLING AGENTS FOR THE SYNTHESIS OF POLYPEPTIDES AND POLYNUCLEOTIDES<br/>[FR] AGENTS DE COUPLAGE POUR LA SYNTHÈSE DE POLYPEPTIDES ET DE POLYNUCLÉOTIDES
  申请人：LUXEMBOURG BIO TECHNOLOGIES LT

  公开号：WO2009138985A2

  公开（公告）日：2009-11-19

  Novel coupling agents containing a unique leaving group moiety, which can be used beneficially and safely as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization suppressing coupling agents for use in peptide syntheses, are disclosed. Also disclosed are processes of preparing such coupling agents and their use in the preparation of polypeptides and/or polynucleotides.