2-amino-4-(1-azido-2-naphthalen-2-yl-2-oxoethyl)-4H-chromene-3-carbonitrile | 1321475-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-amino-4-(1-azido-2-naphthalen-2-yl-2-oxoethyl)-4H-chromene-3-carbonitrile
• CAS: 1321475-01-7
• 化学式: C₂₂H₁₅N₅O₂
• 分子量: 381.393
• InChiKey: BFZGRIJWCXYREL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  90.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  水杨醛 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 1.25h， 生成 2-amino-4-(1-azido-2-naphthalen-2-yl-2-oxoethyl)-4H-chromene-3-carbonitrile
  参考文献：
  名称：

  Michael addition of α-azido ketones on iminocoumarin derivatives: an efficient access to new functionalized azido chromenes

  摘要：

  A facile one-pot synthesis of functionalized azido chromenes was achieved by Michael addition of alpha-azido ketones on iminocoumarin derivatives obtained from salicylaldehydes and malononitrile. Synthesized azido chromenes were successfully transformed into triazolyl chromenes by the [3+2] cycloaddition reaction. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.101

文献信息

• Michael addition of α-azido ketones on iminocoumarin derivatives: an efficient access to new functionalized azido chromenes
  作者：Thelagathoti Hari Babu、Jayabal Kamalraja、Doraiswamy Muralidharan、Paramasivan T. Perumal

  DOI：10.1016/j.tetlet.2011.05.101

  日期：2011.8

  A facile one-pot synthesis of functionalized azido chromenes was achieved by Michael addition of alpha-azido ketones on iminocoumarin derivatives obtained from salicylaldehydes and malononitrile. Synthesized azido chromenes were successfully transformed into triazolyl chromenes by the [3+2] cycloaddition reaction. (C) 2011 Elsevier Ltd. All rights reserved.