((6-Bromo-2-(Hydroxymethyl)Benzo[b]Thiophen-5-yl)Difluoromethyl)Phosphonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: ((6-Bromo-2-(Hydroxymethyl)Benzo[b]Thiophen-5-yl)Difluoromethyl)Phosphonate
• 英文别名: [[6-bromo-2-(hydroxymethyl)-1-benzothiophen-5-yl]-difluoromethyl]phosphonic acid
• 化学式: C₁₀H₈BrF₂O₄PS
• 分子量: 373.11
• InChiKey: WWIKGONDKIGLQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY<br/>[FR] INHIBITEURS DE TC-PTP EN TANT QU'ACTIVATEURS D'APC POUR L'IMMUNOTHÉRAPIE
  申请人：UNIV MCGILL

  公开号：WO2015127548A1

  公开（公告）日：2015-09-03

  The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

  该发明涵盖了以下式（I）所代表的新型化合物类别，这些化合物是TC-PTP酶的抑制剂。该发明还涵盖了包括上述化合物的药物组合物，以及利用这些化合物通过激活抗原递呈细胞（如树突状细胞）来治疗或预防TC-PTP介导的疾病，包括癌症的方法，用于免疫治疗治疗疾病。
• TC-PTP inhibitors as APC activators for immunotherapy
  申请人：THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY

  公开号：US10005804B2

  公开（公告）日：2018-06-26

  The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

  本发明包括下式（I）所代表的一类新型化合物，它们是 TC-PTP 酶的抑制剂。本发明还包括包含上述化合物的药物组合物，以及通过使用这些化合物激活抗原递呈细胞（如树突状细胞）来治疗或预防 TC-PTP 介导的疾病（包括癌症）的方法，这些化合物可应用于疾病的免疫治疗。
• TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY
  申请人：The Royal Institution for the Advancement of Learning / McGill University

  公开号：EP3110824A1

  公开（公告）日：2017-01-04
• ENHANCING CD8+ T CELLS FOR ADOPTIVE T CELL THERAPY BY INHIBITING PTPN1 (PTP1B) AND PTPN2 (TC-PTP)
  申请人：The Royal Institution for the Advancement of Learning/McGill University

  公开号：US20210155645A1

  公开（公告）日：2021-05-27

  The invention encompasses ex vivo method of stimulating isolated memory T-cell, tumor-infiltrating lymphocyte (TIL), T cell receptor (TCR) engineered cell, and/or chimeric antigen receptor (CAR) engineered cell with compounds of Formula I below, which are inhibitors of the TC-PTP enzyme.
• US9828399B2
  申请人：——

  公开号：US9828399B2

  公开（公告）日：2017-11-28