ethyl 2-methyl-1-naphthyloxoacetate | 951888-72-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ethyl 2-methyl-1-naphthyloxoacetate
• 英文别名: Ethyl 2-methyl-1-naphthoylformate；ethyl 2-(2-methylnaphthalen-1-yl)-2-oxoacetate
• CAS: 951888-72-5
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: NUQYTOHXWRLOSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-氯-2-甲基-萘 、 草酰氯单乙酯 在 lithium 作用下， 以 乙醚 为溶剂， 生成 ethyl 2-methyl-1-naphthyloxoacetate
  参考文献：
  名称：

  Aryllithiums with Increasing Steric Crowding and Lipophilicity Prepared from Chlorides in Diethyl Ether. The First Directly Prepared Room-Temperature-Stable Dilithioarenes

  摘要：

  A convenient procedure has been developed for the preparation of synthetically useful, room-temperature-stable aryllithiums starting from aryl chlorides and lithium metal. The method provides a route to aryllithiums which have previously not been accessible cleanly or could only be prepared by using more expensive starting materials.

  DOI：

  10.1021/ol302672n

文献信息

• Aryllithiums with Increasing Steric Crowding and Lipophilicity Prepared from Chlorides in Diethyl Ether. The First Directly Prepared Room-Temperature-Stable Dilithioarenes
  作者：Constantinos G. Screttas、Barry R. Steele、Maria Micha-Screttas、Georgios A. Heropoulos

  DOI：10.1021/ol302672n

  日期：2012.11.16

  A convenient procedure has been developed for the preparation of synthetically useful, room-temperature-stable aryllithiums starting from aryl chlorides and lithium metal. The method provides a route to aryllithiums which have previously not been accessible cleanly or could only be prepared by using more expensive starting materials.