N-(5-methyl-[1,3,4]thiadiazol-2-yl)-isobutyramide | 62347-16-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(5-methyl-[1,3,4]thiadiazol-2-yl)-isobutyramide
• 英文别名: N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-methylpropanamide；Propanamide, 2-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-；2-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)propanamide
• CAS: 62347-16-4
• 化学式: C₇H₁₁N₃OS
• mdl: MFCD00845230
• 分子量: 185.25
• InChiKey: UNQGCISQMCVIDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-5-甲基-1,3,4-噻二唑 、 异丁酸酐 在 anhydride 、 乙酸乙酯 作用下， 反应 2.0h， 以to give N-(5-methyl-1,3,4-thiadiazole-2-yl)-2-methylpropanamide as golden needles的产率得到N-(5-methyl-[1,3,4]thiadiazol-2-yl)-isobutyramide
  参考文献：
  名称：

  Certain acylamino-oxa (or thia) diazoles in treatment of

  摘要：

  Acylamino杂环芳基化合物，其中杂环芳基核是1,3,4-噁二唑或1,3,4-噻二唑核，制备这些化合物的方法以及含有这些化合物的药物制剂。这些化合物具有抗过敏活性。

  公开号：

  US04152442A1

文献信息

• [EN] BIPYRIDINE SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES OR CONDITIONS<br/>[FR] DÉRIVÉS DE BIPYRIDINE-SULFONAMIDE POUR LE TRAITEMENT DE MALADIES ET D'AFFECTIONS NEURODÉGÉNÉRATIVES
  申请人：NOSCIRA SA

  公开号：WO2012069428A1

  公开（公告）日：2012-05-31

  The present invention relates to novel bipyridine sulfonamide derivatives of formula (I) and their use for the treatment and/or prophylaxis of a neurodegenerative disease or condition, particularly Alzheimers disease (AD), a cardiovascular disease or a pathology involving ischemia.. Additionally, processes for preparing such derivatives5 and pharmaceutical compositions comprising them are provided.

  本发明涉及公式（I）的新型双吡啶磺胺衍生物及其用于治疗和/或预防神经退行性疾病或症状，特别是阿尔茨海默病（AD）、心血管疾病或涉及缺血的病理的用途。此外，还提供了制备这种衍生物的方法和包含它们的药物组合物。
• Certain acylamino-oxa (or thia) diazoles in treatment of
  申请人：Lilly Industries Limited

  公开号：US04152442A1

  公开（公告）日：1979-05-01

  Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.

  Acylamino杂环芳基化合物，其中杂环芳基核是1,3,4-噁二唑或1,3,4-噻二唑核，制备这些化合物的方法以及含有这些化合物的药物制剂。这些化合物具有抗过敏活性。
• COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR
  申请人：RYDER Sean

  公开号：US20110065704A1

  公开（公告）日：2011-03-17

  The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
• CARBOCYCLIC SULFONE ROR GAMMA MODULATORS
  申请人：BRISTROL-MYERS SQUIBB COMPANY

  公开号：US20160326103A1

  公开（公告）日：2016-11-10

  Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
• US4152442A
  申请人：——

  公开号：US4152442A

  公开（公告）日：1979-05-01