2-chloro-N-[1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]propyl]-N-(2-phenylethyl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-chloro-N-[1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]propyl]-N-(2-phenylethyl)benzamide
• 化学式: C₃₄H₃₂ClN₃O₃
• 分子量: 566.1
• InChiKey: YOFYMYLSWBMDMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  41
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  62.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Compositions and Methods of Treatment of Cancer
  申请人：Minerva Biotechnologies Corporation

  公开号：EP2116248A1

  公开（公告）日：2009-11-11

  This invention generally relates to compositions and methods for cancer treatment and, in particular, to compositions able to interact with (e.g. bind to) MUC1 growth factor receptor or its ligands. The invention also relates to assays or use of such compositions for the treatment of patients susceptible to or exhibiting symptoms characteristic of cancer or tumorigenesis. Other compositions of the present invention useful for the treatment or prevention of cancer or tumorigenesis include homologs, analogs, derivatives, enantiomers or functional equivalents. The present compositions can also be packaged in kits in some cases.

  本发明一般涉及用于癌症治疗的组合物和方法，尤其涉及能够与 MUC1 生长因子受体或其配体相互作用（例如结合）的组合物。本发明还涉及检测或使用此类组合物治疗易患癌症或表现出癌症或肿瘤发生特征症状的患者。本发明中其他用于治疗或预防癌症或肿瘤发生的组合物包括同系物、类似物、衍生物、对映体或功能等同物。在某些情况下，本发明组合物还可以包装成试剂盒。
• Compositions and methods of treatment of cancer
  申请人：Minerva Biotechnologies Corporation

  公开号：EP2329822A1

  公开（公告）日：2011-06-08

  This invention generally relates to compositions and methods for cancer treatment and, in particular, to compositions able to interact with (e.g. bind to) MUC1 growth factor receptor or its ligands. The invention also relates to assays or use of such compositions for the treatment of patients susceptible to or exhibiting symptoms characteristic of cancer or tumorigenesis. Other compositions of the present invention useful for the treatment or prevention of cancer or tumorigenesis include homologs, analogs, derivatives, enantiomers or functional equivalents. The present compositions can also be packaged in kits in some cases.

  本发明一般涉及用于癌症治疗的组合物和方法，尤其涉及能够与 MUC1 生长因子受体或其配体相互作用（例如结合）的组合物。本发明还涉及检测或使用此类组合物治疗易患癌症或表现出癌症或肿瘤发生特征症状的患者。本发明中其他用于治疗或预防癌症或肿瘤发生的组合物包括同系物、类似物、衍生物、对映体或功能等同物。在某些情况下，本发明组合物还可以包装成试剂盒。
• Method for stimulating or enhancing proliferation of cells by activating the mucin 1 (MUC1) receptor
  申请人：MINERVA BIOTECHNOLOGIES CORPORATION

  公开号：US10703821B2

  公开（公告）日：2020-07-07

  The present application discloses a method for stimulating or enhancing proliferation of a population of cells by activating MUC1 receptor on the cells.

  本申请公开了一种通过激活细胞上的 MUC1 受体来刺激或增强细胞群体增殖的方法。
• COMPOSITIONS AND METHODS OF TREATMENT OF CANCER
  申请人：Minerva Biotechnologies Corporation

  公开号：EP1425016B1

  公开（公告）日：2010-06-02
• PROLIFERATION OF MUC1 EXPRESSING CELLS
  申请人：Minerva Biotechnologies Corporation

  公开号：EP1875244B1

  公开（公告）日：2019-01-23