7-氧代-7-去乙酰氧基葛杜宁 | 13072-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 中文名称: 7-氧代-7-去乙酰氧基葛杜宁
• 英文名称: 7-Deacetyl-7-oxo-gedunin
• 英文别名: 7-Deacetyl-7-oxogedunin；7-(furan-3-yl)-1,8,12,16,16-pentamethyl-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadec-13-ene-5,15,19-trione
• CAS: 13072-74-7
• 化学式: C₂₆H₃₀O₆
• 分子量: 438.521
• InChiKey: PMISPNORJONCHB-UHFFFAOYSA-N

物化性质

• 熔点：
  260-263 °C
• 沸点：
  588.2±50.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  32
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  86.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20190015423A1

  公开（公告）日：2019-01-17

  The presently disclosed subject matter relates to methods of regulating gene expression in a cell by modulating the length of primary cilia of a cell, wherein such modulation can modulate the mechanosensitivity of the cell. The presently disclosed subject matter also provides for methods of treating ciliopathies and osteoporosis in a subject by increasing the length of primary cilia of a cell in a subject.