4-({(1-cyclopropylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoic acid | 1400700-76-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-({(1-cyclopropylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoic acid
• 英文别名: 4-[(1-Cyclopropylisoquinolin-3-yl)-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid；4-[(1-cyclopropylisoquinolin-3-yl)-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid
• CAS: 1400700-76-6
• 化学式: C₂₇H₂₁F₃N₂O₅S
• 分子量: 542.535
• InChiKey: UABQSNMEADHNIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING VASOMOTOR SYMPTOMS
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP3727383A1

  公开（公告）日：2020-10-28
• [EN] COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING VASOMOTOR SYMPTOMS<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT OU DE PRÉVENTION DE SYMPTÔMES VASOMOTEURS
  申请人：MITSUBISHI TANABE PHARMA CORP

  公开号：WO2019124366A1

  公开（公告）日：2019-06-27

  The present disclosure is directed to compositions comprising as an active ingredient, a lower dose of 4-((1-cyclopropylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl] amino}sulfonyl)benzoic acid or a pharmaceutically acceptable salt thereof for treating or preventing vasomotor symptoms in a subject, and methods which comprises administering the said compound or the pharmaceutically acceptable salt thereof at a lower dose, respectively.