1,1-Didecylhydrazine | 86933-39-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1-Didecylhydrazine
• CAS: 86933-39-3
• 化学式: C₂₀H₄₄N₂
• 分子量: 312.583
• InChiKey: HVNDSPYMEDADIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  22
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 sodium hydroxide 作用下， 反应 2.0h， 生成 1,1-Didecylhydrazine 、 苯甲酸
  参考文献：
  名称：

  Physicochemical properties of benzoic acid N,N-dialkylhydrazides

  摘要：

  Benzoic acid N,N-dialkylhydrazides of the general formula C6H5C(O)NHNR2, R = C4H9, C6H13, C8H17, C10H21, were obtained,. Their solubility, acid-base properties, stability against hydrolysis, distribution between organic and water phases were studied.

  DOI：

  10.1134/s1070363209050120

文献信息

• Expandable and curable polyester composition and method for making same
  申请人：UNIROYAL, INC.

  公开号：EP0083173A1

  公开（公告）日：1983-07-06

  An expandable and curable polyester composition comprising a mixture of a liquid, ethylenically unsaturated polyester resin composition; a peroxide; an organometallic promotor; and a dialkyl or trialkyl hydrazine is disclosed. In addition, a method for forming said expanded and cured polyester resin composition, and the product formed in accordance with said method, an expanded and cured polyester resin composition, is taught.

  本发明公开了一种可膨胀固化的聚酯组合物，该组合物包含一种液态乙烯基不饱和聚酯树脂组合物、一种过氧化物、一种有机金属促进剂和一种二烷基或三烷基肼的混合物。 此外，还教导了一种形成所述膨胀固化聚酯树脂组合物的方法，以及根据所述方法形成的产品--膨胀固化聚酯树脂组合物。
• Lipophilic derivatives of double-stranded ribonucleic acid
  申请人：Alnylam Europe AG

  公开号：EP1852506A2

  公开（公告）日：2007-11-07

  The present invention relates to a double-stranded ribonucleic acid (dsRNA) having improved efficiency of inhibition of gene expression, methods of making the dsRNA, and pharmaceutical compositions comprising the dsRNA. The dsRNA comprises an RNA strand (complementary RNA strand) having a region which is complementary to an RNA transcript of at least a part of a target gene, and at least one covalently linked lipophilic group. The dsRNA are useful for inhibiting the expression of a target gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target gene, as well as methods for treating diseases caused by the expression of the gene.

  本发明涉及一种具有更高的基因表达抑制效率的双链核糖核酸(dsRNA)、制造这种dsRNA的方法以及包含这种dsRNA的药物组合物。dsRNA 包括一条 RNA 链（互补 RNA 链）和至少一个共价连接的亲脂基团，前者具有与靶基因至少一部分的 RNA 转录本互补的区域，后者具有与靶基因至少一部分的 RNA 转录本互补的区域。dsRNA 可用于抑制目的基因的表达，也可用于治疗由目的基因表达引起的疾病。本发明还涉及抑制目的基因表达的方法，以及治疗由基因表达引起的疾病的方法。
• LIPOPHILIC DERIVATIVES OF DOUBLE-STRANDED RIBONUCLEIC ACID
  申请人：Alnylam Europe AG

  公开号：EP1587926A2

  公开（公告）日：2005-10-26
• US4397965A
  申请人：——

  公开号：US4397965A

  公开（公告）日：1983-08-09
• [EN] LIPOPHILIC DERIVATIVES OF DOUBLE-STRANDED RIBONUCLEIC ACID<br/>[FR] DERIVES LIPOPHILES D'ACIDE RIBONUCLEIQUE A DOUBLE BRIN
  申请人：RIBOPHARMA AG

  公开号：WO2004065601A2

  公开（公告）日：2004-08-05

  The present invention relates to a double-stranded ribonucleic acid (dsRNA) having improved efficiency of inhibition of gene expression, methods of making the dsRNA, and pharmaceutical compositions comprising the dsRNA. The dsRNA comprises an RNA strand (complementary RNA strand) having a region which is complementary to an RNA transcript of at least a part of a target gene, and at least one covalently linked lipophilic group. The dsRNA are useful for inhibiting the expression of a target gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target gene, as well as methods for treating diseases caused by the expression of the gene.