1-N,3-N-bis(2-aminoethyl)butane-1,3-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-N,3-N-bis(2-aminoethyl)butane-1,3-diamine
• 化学式: C₈H₂₂N₄
• 分子量: 174.29
• InChiKey: BZIMUUAWBWXXCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  76.1
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• COMPOSITIONS FOR INTRODUCING RNA INTO CELLS
  申请人：ethris GmbH

  公开号：EP3013964A1

  公开（公告）日：2016-05-04
• COMPOSITIONS FOR GASTROINTESTINAL ADMINISTRATION OF RNA
  申请人：Ethris GmbH

  公开号：EP3110954A1

  公开（公告）日：2017-01-04
• [EN] COMPOSITIONS FOR INTRODUCING RNA INTO CELLS<br/>[FR] COMPOSITIONS POUR L'INTRODUCTION D'ARN À L'INTÉRIEUR DE CELLULES
  申请人：ETHRIS GMBH

  公开号：WO2014207231A1

  公开（公告）日：2014-12-31

  The present invention relates to oligomers, polymers and lipidoids comprising characteristic oligo(alkylene amine) moieties which are useful as vehicles for transfecting a cell with RNA. The present invention furthermore relates to a composition comprising at least a nucleic acid and an oligomer or polymer or a lipidoid comprising such oligo(alkylene amine) moieties and to a method of transfecting a cell using said composition. Furthermore, the present invention relates to pharmaceutical compositions and uses.
• [EN] COMPOSITIONS FOR GASTROINTESTINAL ADMINISTRATION OF RNA<br/>[FR] COMPOSITIONS POUR UNE ADMINISTRATION GASTRO-INTESTINALE D'ARN
  申请人：ETHRIS GMBH

  公开号：WO2015128030A1

  公开（公告）日：2015-09-03

  The present invention relates to a pharmaceutical composition comprising a polyribonucleotide (RNA) and a cationic agent, wherein said pharmaceutical composition is formulated as a solid dosage form for administration to the gastrointestinal (Gl) tract. The present invention furthermore relates to the use of such a pharmaceutical composition for systemic delivery of RNA and to a method for systemic delivery of RNA to a subject comprising the step of administering such a pharmaceutical composition to the Gl tract. Furthermore, the present invention relates to a kit.