4-chloro-2-hydroxy-[1]naphthaldehyde | 53653-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-chloro-2-hydroxy-[1]naphthaldehyde
• 英文别名: 4-Chlor-2-hydroxy-[1]naphthaldehyd；4-Chloro-2-hydroxy-1-naphthalenecarboxaldehyde；4-chloro-2-hydroxynaphthalene-1-carbaldehyde
• CAS: 53653-23-9
• 化学式: C₁₁H₇ClO₂
• 分子量: 206.628
• InChiKey: WDZQQLVXLJIHFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,4-二氯-[2]萘酚 在 盐酸 、 sodium hydroxide 、 氯仿 、 溶剂黄146 、 tin(ll) chloride 作用下， 反应 2.0h， 生成 4-chloro-2-hydroxy-[1]naphthaldehyde
  参考文献：
  名称：

  73.β-萘酚和2-羟基-3-萘甲酸乙酯在乙酸钠存在下的氯化反应。4-氯-β-萘酚及其衍生物

  摘要：

  DOI：

  10.1039/jr9450000280

文献信息

• METHOD FOR PRODUCING IRON COMPLEX AND METHOD FOR PRODUCING ESTER COMPOUND USING IRON COMPLEX
  申请人：Kuraray Co., Ltd.

  公开号：EP3476828A1

  公开（公告）日：2019-05-01

  The invention provides a simple and high-yield method for producing an iron dinuclear complex which has, in its molecule, a structure having two iron atoms bonded to each other via one oxygen atom and a ligand structure containing a Schiff base; an ester compound production method which can produce an ester compound with a high yield by the transesterification of an alcohol compound with a carboxylate ester even in the case where the raw material alcohol has a tertiary hydroxyl group which is usually difficult to esterify by transesterification; and an ester compound production method which can produce by transesterification catalyzed by an iron complex a wholly esterified compound, i.e., can esterify all the hydroxyl groups, with a high yield even in the case where the alcohol compound has a plurality of hydroxyl groups. A method for producing an iron complex represented by the general formula (4) or (5) includes a step (I-1) of preparing a precursor solution by mixing in the presence of water an iron salt and a compound represented by the general formula (1), and a step (I-2) of mixing the precursor solution with a compound represented by the general formula (2) or (3). A method for producing an ester compound includes a step (IV) of transesterifying a carboxylate ester with an alcohol compound in the presence of the iron complex described above.

  本发明提供了一种生产铁双核络合物的简单而高产的方法，该络合物的分子中具有两个铁原子通过一个氧原子相互结合的结构和一个含有希夫碱的配体结构；一种酯类化合物生产方法，该方法可通过醇类化合物与羧酸酯的酯交换反应高产率地生产酯类化合物，即使原料醇具有通常难以通过酯交换反应酯化的叔羟基；以及一种酯类化合物生产方法，该方法可通过铁络合物催化的酯交换反应生产完全酯化的化合物，即e.,即使在醇类化合物具有多个羟基的情况下，也能以高产率酯化所有羟基。一种生产通式(4)或(5)代表的铁络合物的方法，包括在有水的情况下将铁盐和通式(1)代表的化合物混合制备前体溶液的步骤(I-1)，以及将前体溶液与通式(2)或(3)代表的化合物混合的步骤(I-2)。生产酯类化合物的方法包括在上述铁络合物存在下将羧酸酯与醇类化合物进行酯交换反应的步骤（IV）。
• Method for producing iron complexes and method for producing ester compounds using iron complex
  申请人：KURARAY CO., LTD.

  公开号：US10646859B2

  公开（公告）日：2020-05-12

  Disclosed herein is method for producing an iron dinuclear complex having two iron atoms bonded to each other via one oxygen atom and a ligand structure containing a Schiff base, a method which can produce an ester compound in high yield by the transesterification of an alcohol compound with a carboxylate ester even in the case where the raw material alcohol has a tertiary hydroxyl group which is usually difficult to esterify by transesterification, and a method which can produce a wholly esterified compound by transesterification catalyzed by an iron complex.

  本文公开了一种生产铁双核络合物的方法，该络合物具有两个通过一个氧原子相互结合的铁原子和一个含有希夫碱的配体结构；一种通过醇类化合物与羧酸酯的酯交换反应可以高产率生产酯类化合物的方法，即使原料醇具有通常难以通过酯交换反应酯化的叔羟基；以及一种通过铁络合物催化的酯交换反应可以生产完全酯化的化合物的方法。
• METHOD FOR PRODUCING IRON COMPLEXES AND METHOD FOR PRODUCING ESTER COMPOUNDS USING IRON COMPLEX
  申请人：Kuraray Co., Ltd.

  公开号：EP3476828B1

  公开（公告）日：2021-03-17
• US4002423A
  申请人：——

  公开号：US4002423A

  公开（公告）日：1977-01-11
• 73. The chlorination of β-naphthol and ethyl 2-hydroxy-3-naphthoate in presence of sodium acetate. 4-Chloro-β-naphthol and its derivatives
  作者：Harold Burton

  DOI：10.1039/jr9450000280

  日期：——