2,2,3,3,4,4,4-heptafluoro-N-(3-methoxyphenyl)butanamide | 550302-16-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 2,2,3,3,4,4,4-heptafluoro-N-(3-methoxyphenyl)butanamide
• CAS: 550302-16-4
• 化学式: C₁₁H₈F₇NO₂
• 分子量: 319.179
• InChiKey: RQKFJVQTGLVHSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2,2,3,3,4,4,4-heptafluoro-N-(3-methoxyphenyl)butanamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以61%的产率得到
  参考文献：
  名称：

  Synthesis of fluorinated rhodamines and application for confocal laser scanning microscopy

  摘要：

  Four different fluorinated fluorescence dyes were prepared by attaching perfluoroalkyl ponytails (including CH2 or C2H4 spacer) to each of the two amine groups of rhodamine (Rh) and characterized with respect to their fluorescence properties in 2,2,2-trifluoroethanol (TFE), N,N-dimethylformamide (DMF), tetrahydrofuran (THF), and toluene. They showed an excellent quantum yield in TFE. Double staining with Rh-C2H4-C10F21 and Rh-DPPE Was employed to visualize the distribution of perfluoropalmitic acid in mixed giant unilamellar vesicles with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) observed by confocal laser scanning microscopy. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2016.07.025
• 作为产物：
  描述：

  间氨基苯甲醚 、 七氟丁酸酐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以54%的产率得到2,2,3,3,4,4,4-heptafluoro-N-(3-methoxyphenyl)butanamide
  参考文献：
  名称：

  Synthesis of fluorinated rhodamines and application for confocal laser scanning microscopy

  摘要：

  Four different fluorinated fluorescence dyes were prepared by attaching perfluoroalkyl ponytails (including CH2 or C2H4 spacer) to each of the two amine groups of rhodamine (Rh) and characterized with respect to their fluorescence properties in 2,2,2-trifluoroethanol (TFE), N,N-dimethylformamide (DMF), tetrahydrofuran (THF), and toluene. They showed an excellent quantum yield in TFE. Double staining with Rh-C2H4-C10F21 and Rh-DPPE Was employed to visualize the distribution of perfluoropalmitic acid in mixed giant unilamellar vesicles with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) observed by confocal laser scanning microscopy. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2016.07.025

文献信息

• Synthesis of fluorinated rhodamines and application for confocal laser scanning microscopy
  作者：Mark Jbeily、Regina Schöps、Jörg Kressler

  DOI：10.1016/j.jfluchem.2016.07.025

  日期：2016.9

  Four different fluorinated fluorescence dyes were prepared by attaching perfluoroalkyl ponytails (including CH2 or C2H4 spacer) to each of the two amine groups of rhodamine (Rh) and characterized with respect to their fluorescence properties in 2,2,2-trifluoroethanol (TFE), N,N-dimethylformamide (DMF), tetrahydrofuran (THF), and toluene. They showed an excellent quantum yield in TFE. Double staining with Rh-C2H4-C10F21 and Rh-DPPE Was employed to visualize the distribution of perfluoropalmitic acid in mixed giant unilamellar vesicles with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) observed by confocal laser scanning microscopy. (C) 2016 Elsevier B.V. All rights reserved.