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    • 喹啉
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    首页 分子通 2-[(4-methylbenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid

    2-[(4-methylbenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid

    分子结构分类

    有机化合物 - 有机杂环化合物 - 环七噻吩
    中文名称
    ——
    中文别名
    ——
    英文名称
    2-[(4-methylbenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid
    英文别名
    ——
    2-[(4-methylbenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid化学式
    CAS
    ——
    化学式
    C18H19NO3S
    mdl
    ——
    分子量
    329.4
    InChiKey
    ZTOMHNQMRUBYGE-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      5
    • 重原子数：
      23
    • 可旋转键数：
      3
    • 环数：
      3.0
    • sp3杂化的碳原子比例：
      0.33
    • 拓扑面积：
      94.6
    • 氢给体数：
      2
    • 氢受体数：
      4

    文献信息

    • INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS
      申请人：Verkman Alan S.
      公开号：US20110015239A1
      公开（公告）日：2011-01-20
      Provided herein are methods for identifying compounds that are inhibitors of a calcium-activated chloride channel. Aminothiophene and aminothiazole compounds, and compositions comprising these compounds, described herein that inhibit efflux of chloride through a calcium-activated chloride channel are useful for treating diseases, disorders, and sequalae of diseases, disorders, and conditions that are associated with aberrantly increased chloride and fluid secretion, for example, secretory diarrhea.
    • FUSED THIOPHENE DERIVATIVES AND THEIR USES
      申请人：ENYO PHARMA
      公开号：US20200369682A1
      公开（公告）日：2020-11-26
      The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
    • US9789095B2
      申请人：——
      公开号：US9789095B2
      公开（公告）日：2017-10-17
    • [EN] INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS<br/>[FR] INHIBITEURS DES CANAUX CHLORURE ACTIVES PAR LE CALCIUM
      申请人：UNIV CALIFORNIA
      公开号：WO2009079373A2
      公开（公告）日：2009-06-25
      Provided herein are methods for identifying compounds that are inhibitors of a calcium-activated chloride channel. Aminothiophene and aminothiazole compounds, and compositions comprising these compounds, described herein that inhibit efflux of chloride through a calcium-activated chloride channel are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased chloride and fluid secretion, for example, secretory diarrhea.
    查看更多

    同类化合物

    酮替芬EP杂质A 酮替芬 苯噻啶苹果酸盐 苯噻啶盐酸盐 苯噻啶 益托洛替芬 富马酸酮替芬 去甲酮替芬富马酸氢盐 乙基2-[(乙基氨基甲硫杂酰)氨基]-5,6,7,8-四氢-4H-环庚三烯并[b]噻吩-3-羧酸酯 [2,3-d]噻吩并环庚三烯酮 9-氧代酮替芬 9,10-二溴-9,10-二氢-4H-苯并[4,5]环庚并[1,2-b]噻吩-4-酮 9,10-二氧代酮替芬 9, 10-二氢-4H-苯并[4, 5]环庚三烯[1, 2-b]噻吩-4-酮 6H-环庚三烯并[c]噻吩-6-酮,1,3,5,7-四甲基- 5,6,7,8-四氢-4h-环庚基[b]噻吩-2-羧酸 5,6,7,8-四氢-4H-环庚[b]噻吩-2-羧酸酰肼 4-羟基酮替芬 4-(哌啶-4-亚基)-4H-苯并[4,5]环庚三烯并[1,2-B]噻吩-10(9H)-酮 4-(3'-甲基氨基丙基亚基)-9,10-二氢-4H-苯并(4,5)环庚并(1,2-b)噻吩 4,9-二氢-4-(1-甲基-4-哌啶基亚基)-10H-苯并[4,5]环庚三烯并[1,2-b]噻吩-10-酮 N-氧化物; 酮替芬 N-氧化物 2-溴-9,10-二氢-4H-苯并(4,5)环庚并(1,2-b)噻吩-4-酮 2-氯-N-(3-氰基-5,6,7,8-四氢-4H-环戊并[b]噻吩-2-基)-乙酰胺 2-氨基环庚烷并[B]噻吩-3-羧酸乙酯 2-氨基-N-甲基-5,6,7,8-四氢-4H-环庚并[b]噻吩-3-甲酰胺 2-氨基-N-乙基-5,6,7,8-四氢-4H-环庚并[b]噻吩-3-甲酰胺 2-氨基-5,6,7,8-四氢-4H-环庚基[b]噻吩-3-羧酰胺 2-氨基-5,6,7,8-四氢-4H-环庚基[b]噻吩-3-甲腈 2-氨基-5,6,7,8-四氢-4H-环庚[B]噻吩-3-甲酸甲酯 2-[(3-氯-1-氧代丙基)氨基]-5,6,7,8-四氢-4H-环庚并[b]噻吩-3-羧酸乙酯 2-(2-氯乙酰基氨基)-5,6,7,8-四氢-4H-环庚[b]噻吩-3-羧酸乙酯 10-甲氧基-4H-苯并[4,5]环庚三烯并[1,2-b]噻吩-4-酮 10-甲氧基-4-(1-甲基-4-哌啶基)-4H-苯并[4,5]环庚三烯并[1,2-B]噻吩-4-醇 (3E)-3-(9,10-二氢-4H-苯并[4,5]环庚三烯并[1,2-b]噻吩-4-亚基)-N,N-二甲基丙烷-1-胺 10-methoxy-8-nitro-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-b]thiophene 1,7,9-trimethyl-1,4,5,6-tetrahydrothieno[3',4':6,7]cyclohepta[1,2-c]pyrazole NGB-4420 4-[(Z)-1-phenylbutylidene]-4,6,7,8-tetrahydrocyclohepta[b]thiophen-5-one N-[3-(cyclobutylcarbonyl)-5,6,7,8-tetrahydro-4H-5,8-epoxycyclohepta[b]thien-2-yl]-N'-(1,1-dimethylpropyl)urea (2-amino-5,6,7,8-tetrahydro-4H-5,8-epoxycyclohepta[b]thien-3-yl)(cyclobutyl)methanone 2-[3-(3-methyl[1,2,4]oxadiazol-5-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-ylcarbamoyl]cyclopent-1-enecarboxylic acid 2,8-dihexylcyclohepta[2,1-b:3,4-b']dithiophene methyl 2-(4-methylphenyl)-7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxylate ethyl 2-(3-(naphthalen-1-yl)thioureido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate 2-amino-N-(2-pyridinyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide 2-amino-N-cyclohexyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide isopropyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate 4-allyl-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene PCM-0102200 4-{1-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]piperidin-4-ylidene}-4H-benzo[4,5]cyclohepta[1,2-b]thiophene-10(9H)one hydrobromide

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