2-(2-hydroxymethyl-3-benzofuranyl)pent-4-enol | 147021-96-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-(2-hydroxymethyl-3-benzofuranyl)pent-4-enol
• 英文别名: 2-[2-(Hydroxymethyl)-1-benzofuran-3-yl]pent-4-en-1-ol
• CAS: 147021-96-3
• 化学式: C₁₄H₁₆O₃
• 分子量: 232.279
• InChiKey: ZWUIQHOZBJKZFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  53.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-hydroxymethyl-3-benzofuranyl)pent-4-enol 在 sodium periodate 、 四氧化锇 、 正丁基锂 作用下， 以 水 、 叔丁醇 为溶剂， 反应 2.0h， 生成 3,4-dihydro-1H-pyrano<3,4-b>benzofuran-4-acetaldehyde
  参考文献：
  名称：

  Synthesis of 4-substituted hex-4-enoic and hept-5-enoic acid derivatives of 3,4-dihydro-1H-pyrano[3,4-b] benzofuran as analogues of the 1,3-dioxane thromboxane receptor antagonists

  摘要：

  The synthesis and thromboxane receptor antagonist activity of acidic derivatives of the novel ring system 3,4-dihydro-1H-pyrano [3,4-b] benzofuran are described as tricyclic analogues of the 4(2-hydroxyphenyl) - 1,3-dioxane thromboxane receptor antagonists. These compounds were 50-100 times less potent than the corresponding 1,3-dioxanes.

  DOI：

  10.1016/0223-5234(92)90093-g
• 作为产物：
  描述：

  3-Methoxycarbonylmethylbenzofuran-2-carboxylic acid methyl ester 在 红铝 、 lithium diisopropyl amide 作用下， 以 甲苯 为溶剂， 反应 4.83h， 生成 2-(2-hydroxymethyl-3-benzofuranyl)pent-4-enol
  参考文献：
  名称：

  Synthesis of 4-substituted hex-4-enoic and hept-5-enoic acid derivatives of 3,4-dihydro-1H-pyrano[3,4-b] benzofuran as analogues of the 1,3-dioxane thromboxane receptor antagonists

  摘要：

  The synthesis and thromboxane receptor antagonist activity of acidic derivatives of the novel ring system 3,4-dihydro-1H-pyrano [3,4-b] benzofuran are described as tricyclic analogues of the 4(2-hydroxyphenyl) - 1,3-dioxane thromboxane receptor antagonists. These compounds were 50-100 times less potent than the corresponding 1,3-dioxanes.

  DOI：

  10.1016/0223-5234(92)90093-g

文献信息

• Synthesis of 4-substituted hex-4-enoic and hept-5-enoic acid derivatives of 3,4-dihydro-1H-pyrano[3,4-b] benzofuran as analogues of the 1,3-dioxane thromboxane receptor antagonists
  作者：GR Brown、AJ Foubister

  DOI：10.1016/0223-5234(92)90093-g

  日期：1992.10

  The synthesis and thromboxane receptor antagonist activity of acidic derivatives of the novel ring system 3,4-dihydro-1H-pyrano [3,4-b] benzofuran are described as tricyclic analogues of the 4(2-hydroxyphenyl) - 1,3-dioxane thromboxane receptor antagonists. These compounds were 50-100 times less potent than the corresponding 1,3-dioxanes.