4-{[(6-Ethoxy-1,3-benzothiazol-2-yl)sulfanyl]methyl}-6-(morpholin-4-yl)-1,3,5-triazin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 4-{[(6-Ethoxy-1,3-benzothiazol-2-yl)sulfanyl]methyl}-6-(morpholin-4-yl)-1,3,5-triazin-2-amine
• 英文别名: 4-[(6-ethoxy-1,3-benzothiazol-2-yl)sulfanylmethyl]-6-morpholin-4-yl-1,3,5-triazin-2-amine
• 化学式: C₁₇H₂₀N₆O₂S₂
• mdl: MFCD02324755
• 分子量: 404.5
• InChiKey: KYLLVURDBFJKBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  153
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• COMPOUNDS AND METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE
  申请人：YALE UNIVERSITY

  公开号：US20190275040A1

  公开（公告）日：2019-09-12

  The present invention provides methods for treating Alzheimer's Disease, or preventing synaptic death associated with Alzheimer's Disease by administering a Pyk2 inhibitor. In certain embodiments, the Pyk2 inhibitor is specific for Pyk2. In other embodiments, the Pyk2 inhibitor also inhibits Fyn.
• [EN] COMPOUNDS AND METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE<br/>[FR] COMPOSÉS, ET MÉTHODES DE TRAITEMENT OU DE PRÉVENTION DE LA MALADIE D'ALZHEIMER
  申请人：UNIV YALE

  公开号：WO2018058098A1

  公开（公告）日：2018-03-29

  The present invention provides methods for treating Alzheimer's Disease, or preventing synaptic death associated with Alzheimer's Disease by administering a Pyk2 inhibitor. In certain embodiments, the Pyk2 inhibitor is specific for Pyk2. In other embodiments, the Pyk2 inhibitor also inhibits Fyn.