cis-2,5-dimethyl-1,3-dioxane | 15042-57-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: cis-2,5-dimethyl-1,3-dioxane
• 英文别名: cis-2,5-dimethyl-1,3-dioxan
• CAS: 15042-57-6
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: RPMUDXVQHUECRE-OLQVQODUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.02
• 重原子数：
  8.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2-甲基-5-亚甲基-[1,3]二恶烷 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 为溶剂， 生成 cis-2,5-dimethyl-1,3-dioxane
  参考文献：
  名称：

  Ishiyama, Jun-ichi; Senda, Yasuhisa; Imaizumi, Shin, Journal of the Chemical Society. Perkin transactions II, 1982, p. 71 - 76

  摘要：

  DOI：

文献信息

• SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AS AGGRECANASE INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
  申请人：MERCK PATENT GMBH

  公开号：US20150368188A1

  公开（公告）日：2015-12-24

  The present invention relates to compounds of the formula I and in particular medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which ADAMTS5 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.

  本发明涉及公式I的化合物，特别是包括至少一种公式I的化合物的药物，用于治疗和/或预防生理和/或病理状态，在其中ADAMTS5参与诱发，特别是用于治疗和/或预防骨关节炎、肝硬化、创伤性软骨损伤、疼痛、触发性痛或过敏性痛。
• Zorin, V. V.; Kukovitskii, D. M.; Todres, Z. V., Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, p. 1635 - 1638
  作者：Zorin, V. V.、Kukovitskii, D. M.、Todres, Z. V.、Zlot-skii, S. S.、Rakhmankulov, D. L.

  DOI：——

  日期：——
• COMPOUND, LIQUID CRYSTAL COMPOSITION AND HIGH-FREQUENCY PHASE SHIFTER
  申请人：DIC Corporation

  公开号：US20210179943A1

  公开（公告）日：2021-06-17

  The present invention provides a compound represented by the following general formula (I), and provides a liquid crystal composition containing the compound and a device using the liquid crystal composition. The compound of the present invention has a large refractive index anisotropy Δn and a high compatibility with a liquid crystal composition, and exhibits a large dielectric constant anisotropy in a high frequency region; and therefore, it is useful as a material for a device of a high-frequency phase shifter, a phased array antenna, an image recognition device, distance measuring equipment, a liquid crystal display device, a liquid crystal lens, a birefringent lens for stereoscopic image display, or the like.
• COMPOUND, LIQUID-CRYSTAL COMPOSITION, AND RADIOFREQUENCY PHASE SHIFTER
  申请人：DIC Corporation

  公开号：US20220025264A1

  公开（公告）日：2022-01-27

  A compound is represented by general formula (I), a liquid-crystal composition contains this compound, and devices are made using this liquid-crystal composition. Having a large refractive-index anisotropy Δn and a sufficiently high Tni, highly compatible with liquid-crystal compositions, and exhibiting a high dielectric anisotropy in the radiofrequency range, the compound is a useful material for RF phase shifters, phased-array antennae, image recognition devices, distance meters, liquid-crystal displays, liquid-crystal lenses, and birefringent lenses for 3D image display, among other devices.
• US9656949B2
  申请人：——

  公开号：US9656949B2

  公开（公告）日：2017-05-23