1-(1-Adamantyl)piperidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(1-Adamantyl)piperidin-2-one
• 化学式: C₁₅H₂₃NO
• 分子量: 233.35
• InChiKey: JEBHNKYSIIPZJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(1-Adamantyl)piperidin-2-one 、 lithium diisopropyl amide 、 2,6-二氯氯苄 、 水 在 氮 、 乙酸乙酯 、 Brine 、 magnesium sulfate 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 以to give the title compound (0.14 g, 15%) as a colorless solid的产率得到1-(1-Adamantyl)-3-(2,6-dichlorobenzyl)piperidin-2-one
  参考文献：
  名称：

  Prophylactic/Therapeutic Agent for Diabetes

  摘要：

  本发明涉及一种11β-羟基类固醇脱氢酶1抑制剂，其包括由式（1）表示的化合物，其中每个符号如描述中所定义的，或其盐或前药。本发明的11β-羟基类固醇脱氢酶1抑制剂具有优异的活性，可用作药物剂，如用于预防或治疗糖尿病、胰岛素抵抗、肥胖症、异常脂质代谢、高血压等的药剂。

  公开号：

  US20090264650A1

文献信息

• PROPHYLACTIC/THERAPEUTIC AGENT FOR DIABETES
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1864971A1

  公开（公告）日：2007-12-12

  The present invention relates to a 11β-hydroxysteroid dehydrogenase 1 inhibitor comprising a compound represented by the formula (1): wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof. The 11β-hydroxysteroid dehydrogenase 1 inhibitor of the present invention has a superior activity, and is useful as a pharmaceutical agent such as agents for the prophylaxis or treatment of diabetes, insulin resistance, obesity, abnormal lipid metabolism, hypertension and the like, and the like.

  本发明涉及一种 11β-羟基类固醇脱氢酶 1 抑制剂，由式（1）代表的化合物组成： 其中各符号如说明中所定义，或其盐，或其原药。本发明的11β-羟类固醇脱氢酶1抑制剂具有优异的活性，可作为药物制剂，如用于预防或治疗糖尿病、胰岛素抵抗、肥胖、脂代谢异常、高血压等疾病的药物。
• METHODS FOR AUTHENTICATION AND IDENTIFICATION OF PETROLEUM PRODUCTS
  申请人：Exxonmobil Research And Engineering Company

  公开号：EP3237903A1

  公开（公告）日：2017-11-01
• METHODS FOR DETERMINING CONDITION AND QUALITY OF PETROLEUM PRODUCTS
  申请人：Exxonmobil Research And Engineering Company

  公开号：EP3237904A1

  公开（公告）日：2017-11-01
• [EN] METHODS FOR AUTHENTICATION AND IDENTIFICATION OF PETROLEUM PRODUCTS<br/>[FR] PROCÉDÉS D'AUTHENTIFICATION ET D'IDENTIFICATION DE PRODUITS PÉTROLIERS
  申请人：EXXONMOBIL RES & ENG CO

  公开号：WO2016106211A1

  公开（公告）日：2016-06-30

  A method is provided that associates a taggant with a product to produce a signature product. The taggant, when associated with the signature product, is visually undetectable; and comprises one or more amide compounds (e.g., a taggant array that comprises two or more amide compounds). The method also identifies the taggant in the signature product by an immunoassay specific for the taggant; maps the taggant of the signature product to a batch code of the signature product; obtains a test product to determine authenticity or identity of the test product; identifies the presence or absence of a taggant in the test product by an immunoassay specific for the taggant; and compares results of the immunoassay carried out on the test product with results of the immunoassay carried out on the signature product to determine authenticity or identity of the test product. Lubricating engine oils are provided containing the taggant.
• [EN] METHODS FOR DETERMINING CONDITION AND QUALITY OF PETROLEUM PRODUCTS<br/>[FR] PROCÉDÉS DE DÉTERMINATION D'ÉTAT ET DE QUALITÉ DE PRODUITS PÉTROLIERS
  申请人：EXXONMOBIL RES & ENG CO

  公开号：WO2016106214A1

  公开（公告）日：2016-06-30

  A method is provided for determining the condition or quality of a product. The method involves adding to the product a taggant in which the taggant exhibits degradation in response to one or more stimuli; carrying out an immunoassay specific for the taggant to determine degradation of the taggant; and determining the condition of the product based on the degradation of the taggant. A method is provided for monitoring degradation or quality of a product. The method involves adding to the product a taggant in which the taggant exhibits degradation in response to one or more stimuli; and carrying out an immunoassay specific for the taggant to determine degradation of the taggant. The method further involves identifying the condition of the product based on the degradation of the taggant. Lubricating engine oils are provided containing the taggant.