N-[2-(4-hydroxyphenyl)ethyl] butanamide | 66800-53-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-[2-(4-hydroxyphenyl)ethyl] butanamide
• 英文别名: N-[2-(4-Hydroxyphenyl)ethyl]butanamide
• CAS: 66800-53-1
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: UCELBUIXQQYTKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对羟基苯乙胺 、 辅酶 A S-丁酸酯 在 5,5'-二硫双(2-硝基苯甲酸) 、 Drosophila melanogaster arylalkylamine N-acetyltransferase A from E_. coli 作用下， 以 aq. buffer 为溶剂， 生成 N-[2-(4-hydroxyphenyl)ethyl] butanamide
  参考文献：
  名称：

  Mechanistic and Structural Analysis of Drosophila melanogaster Arylalkylamine N-Acetyltransferases

  摘要：

  Arylalkylamine N-acetyltransferase (AANAT) catalyzes the penultimate step in the biosynthesis of melatonin and other N-acetylarylalkylamides from the corresponding arylalkylamine and acetyl-CoA. The N-acetylation of arylalkylamines is a critical step in Drosophila melanogaster for the inactivation of the bioactive amines and the sclerotization of the cuticle. Two AANAT variants (AANATA and AANATB) have been identified in D. melanogaster, in which AANATA differs from AANATB by the truncation of 35 amino acids from the N-terminus. We have expressed and purified both D. melanogaster AANAT variants (AANATA and AANATB) in Escherichia coli and used the purified enzymes to demonstrate that this N-terminal truncation does not affect the activity of the enzyme. Subsequent characterization of the kinetic and chemical mechanism of AANATA identified an ordered sequential mechanism, with acetyl-CoA binding first, followed by tyramine. We used a combination of pH-activity profiling and site-directed mutagenesis to study prospective residues believed to function in AANATA catalysis. These data led to an assignment of Glu-47 as the general base in catalysis with an apparent pKa of 7.0. Using the data generated for the kinetic mechanism, structure-function relationships, pH-rate profiles, and site-directed mutagenesis, we propose a chemical mechanism for AANATA.

  DOI：

  10.1021/bi5006078

文献信息

• [EN] SUBTYPE-SELECTIVE NMDA RECEPTOR LIGANDS AND THE USE THEREOF<br/>[FR] LIGANDS DU RECEPTEUR N-METHYL-D-ASPARTATE SELECTIFS DE SOUS-TYPE
  申请人：STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON

  公开号：WO1997023202A1

  公开（公告）日：1997-07-03

  (EN) The invention relates to subtype-selective NMDA receptor ligands and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's diseae, Parkinson's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, chronic pain, glaucoma, CMV retinitis, urinary incontinence and inducing anesthesia, as well as for enhancing cognition, treating or preventing opiate tolerance, treating or preventing aminoglycoside antibiotic induced hearing loss, and treating opiate withdrawal.(FR) Cette invention a trait à des ligands du récepteur N-méthyl-D-aspartate (NMDA) sélectifs de sous-type et à leur utilisation dans le traitement ou la prévention de la dépopulation neuronale associée à un ictus, une ischémie, une lésion du système nerveux central, une hypoglycémie et à un acte chirurgical, ainsi que dans le traitement de maladies neurodégénérescentes, au nombre desquelles la maladie d'Alzheimer, la sclérose latérale amyotrophique, les maladies d'Huntington et de Parkinson ainsi que le syndrome de Down. Ces ligands sont également utilisés dans le traitement et la prévention des conséquences préjudiciables d'une stimulation excessive d'acides aminés excitateurs, le traitement de l'anxiété, de psychoses, de convulsions, de douleurs chroniques, du glaucome, de la rétinite à cytomégalovirus, de l'incontinence urinaire et pour le déclenchement de l'anesthésie ainsi que comme tonique cérébro-actif. Ces ligands sont, en outre, utilisés dans le traitement et la prévention de l'accoutumance opiacée et le traitement du sevrage des dépendances aux opiacés ainsi que pour le traitement et la prévention du déficit auditif provoqué par des aminoglycosides.

  本发明涉及亚型选择性NMDA受体配体及其在治疗或预防与中风、缺血、中枢神经系统创伤、低血糖和手术相关的神经元丢失，以及治疗包括阿尔茨海默病、肌萎缩侧索硬化症、亨廷顿病、帕金森病和唐氏综合症在内的神经退行性疾病，治疗或预防兴奋性氨基酸过度刺激的不良后果，治疗焦虑、精神病、癫痫、慢性疼痛、青光眼、CMV视网膜炎、尿失禁和诱导麻醉，以及增强认知能力，治疗或预防阿片类药物耐受性，治疗或预防氨基糖苷类抗生素引起的听力损失，和治疗阿片类药物戒断症状的用途。
• Methods and Compositions for Pest Control
  申请人：Jones Tappey H.

  公开号：US20130289125A1

  公开（公告）日：2013-10-31

  Methods and compositions for pest control, and more particularly for control of ants, e.g., of the subfamily Myrmicinae, using tyramides.

  使用酪胺酸衍生物的方法和组合物，尤其是用于控制蚂蚁，例如亚科Myrmicinae的控制。
• COMPOSITION, THERMALLY CONDUCTIVE MATERIAL, DEVICE WITH THERMALLY CONDUCTIVE LAYER, AND METHOD FOR MANUFACTURING THERMALLY CONDUCTIVE MATERIAL
  申请人：FUJIFILE Corporation

  公开号：US20200291174A1

  公开（公告）日：2020-09-17

  A first object of the present invention is to provide a composition capable of forming a cured product (thermally conductive material) having excellent thermal conductivity. In addition, a second object of the present invention is to provide a thermally conductive material formed from the composition and a device with a thermally conductive layer. In addition, a third object of the present invention is to provide a method for manufacturing a thermally conductive material using the composition. The composition of the present invention includes a curing agent including an active hydrogen-containing functional group, and a main agent including a reactive group which reacts with the active hydrogen-containing functional group, in which the main agent and the curing agent respectively exhibit liquid crystallinity in a single state at a temperature of 150° C. or lower.
• US9950994B2
  申请人：——

  公开号：US9950994B2

  公开（公告）日：2018-04-24
• [EN] Methods and Compositions for Pest Control<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LA LUTTE CONTRE LES NUISIBLES
  申请人：VMI FOUNDATION

  公开号：WO2012061624A2

  公开（公告）日：2012-05-10

  Methods and compositions for pest control, and more particularly for control of ants, e.g., of the subfamily Myrmicinae, using tyramides.