2-[Bis[2-[4-[[4-(4-bromo-2-fluoroanilino)-6-methoxyquinazolin-7-yl]oxymethyl]piperidine-1-carbonyl]oxyethyl]amino]ethyl 4-[[4-(4-bromo-2-fluoroanilino)-6-methoxyquinazolin-7-yl]oxymethyl]piperidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-[Bis[2-[4-[[4-(4-bromo-2-fluoroanilino)-6-methoxyquinazolin-7-yl]oxymethyl]piperidine-1-carbonyl]oxyethyl]amino]ethyl 4-[[4-(4-bromo-2-fluoroanilino)-6-methoxyquinazolin-7-yl]oxymethyl]piperidine-1-carboxylate
• 英文别名: 2-[bis[2-[4-[[4-(4-bromo-2-fluoroanilino)-6-methoxyquinazolin-7-yl]oxymethyl]piperidine-1-carbonyl]oxyethyl]amino]ethyl 4-[[4-(4-bromo-2-fluoroanilino)-6-methoxyquinazolin-7-yl]oxymethyl]piperidine-1-carboxylate
• 化学式: C₇₂H₇₅Br₃F₃N₁₃O₁₂
• 分子量: 1611.2
• InChiKey: XQDFCXSNADAUQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14
• 重原子数：
  103
• 可旋转键数：
  30
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  261
• 氢给体数：
  3
• 氢受体数：
  25

文献信息

• Multivalent ligands targeting VEGFR
  申请人：THE METHODIST HOSPITAL SYSTEM

  公开号：US10011587B2

  公开（公告）日：2018-07-03

  Compounds that target vascular endothelial growth factor receptors for therapy and imaging are disclosed. Methods for making the compounds and detecting or imaging cells expressing VEGFR using the compounds are also provided. In accordance with the purposes of the disclosed subject matter, as embodied and broadly described herein, disclosed are compounds, and methods of making and using the compounds. The disclosed compounds, in one aspect, are quinazoline compounds.

  本研究公开了靶向血管内皮生长因子受体的化合物，用于治疗和成像。还提供了制造该化合物和使用该化合物检测或成像表达血管内皮生长因子受体的细胞的方法。根据所公开主题的目的，如本文所体现和广泛描述的，公开了化合物以及制造和使用化合物的方法。所公开的化合物在一个方面是喹唑啉化合物。
• MULTIVALENT LIGANDS TARGETING VEGFR
  申请人：THE METHODIST HOSPITAL SYSTEM

  公开号：US20170073328A1

  公开（公告）日：2017-03-16

  Compounds that target vascular endothelial growth factor receptors for therapy and imaging are disclosed. Methods for making the compounds and detecting or imaging cells expressing VEGFR using the compounds are also provided. In accordance with the purposes of the disclosed subject matter, as embodied and broadly described herein, disclosed are compounds, and methods of making and using the compounds. The disclosed compounds, in one aspect, are quinazoline compounds.