5-(2-oxononan-4-yl)furan-2(5H)-one | 1241389-13-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 5-(2-oxononan-4-yl)furan-2(5H)-one
• 英文别名: (2R)-2-[(4R)-2-oxononan-4-yl]-2H-furan-5-one
• CAS: 1241389-13-8
• 化学式: C₁₃H₂₀O₃
• 分子量: 224.3
• InChiKey: YDKXSIXZEDDQLR-NEPJUHHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  三甲硅氧基-2-呋喃 、 3-壬烯-2-酮 在 碘 作用下， 以 乙醚 为溶剂， 反应 3.5h， 生成 5-(2-oxononan-4-yl)furan-2(5H)-one 、 (2R)-2-[(4S)-2-oxononan-4-yl]-2H-furan-5-one
  参考文献：
  名称：

  Iodine-catalyzed 1,4-addition of 2-(trimethylsilyloxy)furan to α,β-unsaturated ketones: a facile synthesis of γ-butenolides

  摘要：

  The alpha,beta-unsaturated compounds undergo smooth conjugate addition with 2-(trimethylsilyloxy)furan (TMSF) in the presence of 10 mol % of iodine under mild and neutral conditions to afford the corresponding gamma-substituted butenolides in high yields and with good diastereoselectivity. The use of iodine makes this procedure simple, convenient and cost effective. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.02.128

文献信息

• Iodine-catalyzed 1,4-addition of 2-(trimethylsilyloxy)furan to α,β-unsaturated ketones: a facile synthesis of γ-butenolides
  作者：J.S. Yadav、B.V. Subba Reddy、G. Narasimhulu、N. Sivasankar Reddy、P. Janardhan Reddy

  DOI：10.1016/j.tetlet.2009.02.128

  日期：2009.7

  The alpha,beta-unsaturated compounds undergo smooth conjugate addition with 2-(trimethylsilyloxy)furan (TMSF) in the presence of 10 mol % of iodine under mild and neutral conditions to afford the corresponding gamma-substituted butenolides in high yields and with good diastereoselectivity. The use of iodine makes this procedure simple, convenient and cost effective. (C) 2009 Published by Elsevier Ltd.