1,1,1-Triethyl-hydrazinium | 44634-85-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1,1-Triethyl-hydrazinium
• 英文别名: Amino(triethyl)azanium
• CAS: 44634-85-7
• 化学式: C₆H₁₇N₂
• 分子量: 117.214
• InChiKey: BBVRYTBXVFBTAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS
  申请人：UNIVERSITY OF PUERTO RICO

  公开号：US20190125746A1

  公开（公告）日：2019-05-02

  A series of novel of EHop-016 derivatives is presented herein via designing and synthesizing compounds that mimics its more favorable “U-shaped” conformation that appears to be critical for inhibitory activity against Rac. Based on modeling studies on EHop-016, compounds with a more rigid structural conformation can mimic this “U-shaped” conformation would improve the anti-migration activity against metastatic cells. Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed.

  本文介绍了一系列EHop-016衍生物，通过设计和合成模拟其更有利的“U”形构象的化合物，这对于抑制Rac的活性至关重要。基于对EHop-016的建模研究，具有更严格结构构象的化合物可以模拟这种“U”形构象，从而提高对转移性细胞的抗迁移活性。披露了抑制对抗过度增殖和肿瘤性疾病有用的RhoGTP酶的化合物。具体来说，这些化合物抑制了在癌症和转移中信号通路中过度活跃或过度表达的Rac和Cdc42 GTP酶。还披露了治疗癌症和过度增殖性疾病的方法。
• [EN] PLANT GROWTH REGULATOR COMPOUNDS<br/>[FR] COMPOSÉS RÉGULATEURS DE LA CROISSANCE DES PLANTES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2019175025A1

  公开（公告）日：2019-09-19

  The present invention relates to relates to novel strigolactam derivatives, to processes for preparing these derivatives including intermediate compounds, to seeds comprising these derivatives, 5 to plant growth regulator or seed germination promoting compositions comprising these derivatives and to methods of using these derivatives in controlling the growth of plants and/or promoting the germination of seeds.

  本发明涉及新型链腈内酰胺衍生物，涉及制备这些衍生物的方法，包括中间化合物，含有这些衍生物的种子，含有这些衍生物的植物生长调节剂或促进种子萌发的组合物，以及使用这些衍生物控制植物生长和/或促进种子萌发的方法。
• [EN] STRIGOLACTONE DERIVATIVES AS PLANT GROWTH REGULATOR COMPOUNDS<br/>[FR] DÉRIVÉS DE STRIGOLACTONE UTILISÉS EN TANT QUE COMPOSÉS RÉGULATEURS DE LA CROISSANCE DES PLANTES
  申请人：SYNGENTA CROP PROTECTION AG

  公开号：WO2021043616A1

  公开（公告）日：2021-03-11

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as plant growth regulators and/or seed germination promoters.

  式(I)中的化合物，其中取代基如权利要求1所定义，可用作植物生长调节剂和/或种子发芽促进剂。
• [EN] MANUFACTURING OF STABILIZED PROPARGYL BROMIDE<br/>[FR] FABRICATION DE BROMURE DE PROPARGYLE STABILISÉ
  申请人：BROMINE COMPOUNDS LTD

  公开号：WO2014045278A1

  公开（公告）日：2014-03-27

  This invention provides a process for obtaining propargyl bromide in high yield from propargyl alcohol and phosphorus bromide, in the form of a stable composition with alkylbromide.

  本发明提供了一种从丙炔醇和溴化磷中高收率获得丙炔溴化物的过程，以烷基溴化物的形式制备稳定的组合物。
• Heterocyclic dihydropyrimidine compounds
  申请人：——

  公开号：US20030022890A1

  公开（公告）日：2003-01-30

  Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors K v 1.5 which has been linked to the ultra-rapidly activating delayed rectifier K + current I Kur ), methods of using such compounds in the prevention and treatment of arrhythmia and I Kur -associated conditions, and pharmaceutical compositions containing such compounds.

  本发明涉及一种新型杂环二氢嘧啶化合物，其可作为钾通道功能抑制剂（特别是Kv1亚家族电压门控K+通道的抑制剂，特别是与超快速激活延迟整流K+电流IKur相关的Kv1.5的抑制剂），以及使用这些化合物在预防和治疗心律失常和IKur相关疾病方面的方法，以及含有这些化合物的药物组合物。