N-(3,5-dimethyl-1H-pyrazol-4-yl)acetamide | 300731-86-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(3,5-dimethyl-1H-pyrazol-4-yl)acetamide
• CAS: 300731-86-6
• 化学式: C₇H₁₁N₃O
• mdl: MFCD00652980
• 分子量: 153.18
• InChiKey: ILCJEJQTTQLILC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] NOVEL ANTIVIRAL COMPOUNDS AND METHODS USING SAME<br/>[FR] NOUVEAUX COMPOSÉS ANTIVIRAUX ET LEURS MÉTHODES D'UTILISATION
  申请人：UNIV PENNSYLVANIA

  公开号：WO2015153554A1

  公开（公告）日：2015-10-08

  The present invention includes compounds that are useful in preventing or treating viral infections, such as viral infections caused by a filovirus, arenavirus, rhabdovirus, paramyxovirus, and/or retrovirus. The present invention further includes compositions comprising such compounds, and methods of treating a viral infection in a subject using such compounds.

  本发明包括一些有用的化合物，可用于预防或治疗病毒感染，如由丝状病毒、汉坦病毒、狂犬病毒、副粘病毒和/或逆转录病毒引起的病毒感染。本发明还包括包含这些化合物的组合物，以及使用这些化合物治疗受试者病毒感染的方法。
• TROPOMYOSIN-RELATED KINASE INHIBITORS
  申请人：PFIZER INC

  公开号：US20150322043A1

  公开（公告）日：2015-11-12

  The present invention relates to compounds of Formula I and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

  本发明涉及公式I化合物及其药学上可接受的盐，其中取代基如本文所述，并且它们在医学上的应用，特别是作为TrkA拮抗剂。
• Antiviral compounds and methods using same
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US10160756B2

  公开（公告）日：2018-12-25

  The present invention includes compounds that are useful in preventing or treating viral infections, such as viral infections caused by a filovirus, arenavirus, rhabdovirus, paramyxovirus, and/or retrovirus. The present invention further includes compositions comprising such compounds, and methods of treating a viral infection in a subject using such compounds.

  本发明包括可用于预防或治疗病毒感染的化合物，例如由丝状病毒、腺病毒、横纹肌病毒、副粘病毒和/或逆转录病毒引起的病毒感染。本发明还包括包含此类化合物的组合物，以及使用此类化合物治疗受试者病毒感染的方法。
• NOVEL ANTIVIRAL COMPOUNDS AND METHODS USING SAME
  申请人：The Trustees of The University of Pennsylvania

  公开号：EP3126005A1

  公开（公告）日：2017-02-08
• Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety
  申请人：PFIZER INC.

  公开号：US20170197939A1

  公开（公告）日：2017-07-13

  The present invention relates to compounds of Formula I and their prodrugs and pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.