2-(6,7-Dimethoxy-3,3-dimethyl-2,4-dihydroisoquinolin-1-ylidene)acetamide | 478036-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 2-(6,7-Dimethoxy-3,3-dimethyl-2,4-dihydroisoquinolin-1-ylidene)acetamide
• CAS: 478036-27-0
• 化学式: C₁₅H₂₀N₂O₃
• 分子量: 276.335
• InChiKey: OQRJKZFNEBBXDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(6,7-Dimethoxy-3,3-dimethyl-2,4-dihydroisoquinolin-1-ylidene)acetamide 、 3-benzoylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione 以 乙腈 为溶剂， 反应 0.03h， 以88%的产率得到3-benzoyl-4-hydroxy-1-(2-hydroxyphenyl)-5',5'-dimethyl-8',9'-dimethoxy-3',5-dioxo-1,5,5',6'-tetrahydro-3'H-spiro[pyrrole-2,2'-pyrrolo[2,1-a]isoquinoline]-1'-carboxamide
  参考文献：
  名称：

  Reaction of 3-aroyl-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones with substituted acetamides of 3,4-dihydroisoquinolines

  摘要：

  3-Aroyl-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones react with substituted [3,4-dihydroisoquinolin-1(2H)-ylidene]acetamides and {2,3-dihydrobenzo[f]isoquinolin-4(1H)-ylidene}acetamide to produce substituted 1,5,5',6'-tetrahydro-3'H-spiro(pyrrole-2,2'-pyrrolo[2,1-a]-isoquinoline)-1'-carboxamides and 13-aza-analogs of steroids, substituted 5H-spiro(benzo[f]pyrrolo[2,1-a]isoquinoline-9,2'-pyrrole)-10-carboxamides respectively.

  DOI：

  10.1134/s1070428015110081

文献信息

• Direct heterocyclization of tetrahydroisoquinolin-1-ylideneacetic acids by the action of 5-arylfuran-2,3-diones
  作者：V. V. Khalturina、Yu. V. Shklyaev、Z. G. Aliev、A. N. Maslivets

  DOI：10.1134/s1070428009100297

  日期：2009.10
• Synthesis of Pyrimido[6,1-a]isoquinolines by the Reaction of Thriethyl Orthoformate with Enamines of 3,3-dialkyl-1,2,3,4-tetrahydroisoquinoline series
  作者：A. G. Mikhailovskii、D. A. Peretyagin

  DOI：10.1134/s1070428019050233

  日期：2019.5

  Boiling (Z)-2-[3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene]acetamides in AcOEt/Ac2O leads involves annelation of the pyrimidine ring to form 6,6-dimethyl-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-2-ones. Similarly, benzo[f]isoquinoline amides form in this reaction 12,12-dialkyl-11,12-dihydro-3H-benzo[f]pyrimido[6,1-a]isoquinolin-3-ones.
• Reaction of 3-aroyl-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones with substituted acetamides of 3,4-dihydroisoquinolines
  作者：V. V. Konovalova、A. V. Kharitonova、Yu. V. Shklyaev、A. N. Maslivets

  DOI：10.1134/s1070428015110081

  日期：2015.11

  3-Aroyl-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones react with substituted [3,4-dihydroisoquinolin-1(2H)-ylidene]acetamides and 2,3-dihydrobenzo[f]isoquinolin-4(1H)-ylidene}acetamide to produce substituted 1,5,5',6'-tetrahydro-3'H-spiro(pyrrole-2,2'-pyrrolo[2,1-a]-isoquinoline)-1'-carboxamides and 13-aza-analogs of steroids, substituted 5H-spiro(benzo[f]pyrrolo[2,1-a]isoquinoline-9,2'-pyrrole)-10-carboxamides respectively.