2-[Hydroxy(methoxy)phosphoryl]oxyethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[Hydroxy(methoxy)phosphoryl]oxyethyl-trimethylazanium
• 化学式: C6H17NO4P+
• 分子量: 198.18
• InChiKey: UFOVZASHPZGDNP-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL AMPHIPHILIC DERIVATIVES OF ALPHA-C-PHENYL-N-TERT-BUTYLNITRONE
  申请人：Durand Grégory

  公开号：US20090306001A1

  公开（公告）日：2009-12-10

  Compounds derived from α-C-phenyl-N-tert-butylnitrone, a process for the preparation thereof and use thereof for the preparation of medicaments for use in preventing or treating oxidative stress-related diseases.

  从α-C-苯基-N-叔丁基亚甲基腈衍生的化合物，其制备方法以及用于制备用于预防或治疗与氧化应激相关疾病的药物的用途。
• PROTEIN-STABILIZING AGENT AND PROTEIN-STABILIZING METHOD
  申请人：NOF CORPORATION

  公开号：US20170226499A1

  公开（公告）日：2017-08-10

  There is provided a protein stabilizer containing a compound represented by Formula (1) as an active ingredient. The protein stabilizer is capable of stabilizing a protein in a solution state for a long period of time without affecting an assay system, the protein being not limited to enzymes, labeling substances such as fluorescent substances and chemiluminescent substances, and assay target substances. There is also provided a protein stabilization method containing making the protein coexist with the compound represented by Formula (1) in a water-containing solution. In Formula (1), X is a hydrogen atom or a methyl group, and n is an integer of 3 to 17.

  提供一种蛋白质稳定剂，其含有以化学式（1）表示的化合物作为活性成分。该蛋白质稳定剂能够在不影响测定系统的情况下，长时间稳定溶液状态下的蛋白质，这种蛋白质不仅限于酶、荧光物质和化学发光物质等标记物质，还包括测定目标物质。同时提供一种蛋白质稳定化方法，其中将蛋白质与化学式（1）表示的化合物共存于含水溶液中。在化学式（1）中，X为氢原子或甲基基团，n为3至17的整数。
• MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES
  申请人：Charles Stephen A.

  公开号：US20130045522A1

  公开（公告）日：2013-02-21

  The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.

  本发明提供了含有双离子和一个或多个功能性试剂的随机共聚物，以及制备这种随机共聚物的方法。
• Separation Medium for Biochemical Analysis
  申请人：Masuda Mitsutoshi

  公开号：US20090211907A1

  公开（公告）日：2009-08-27

  The invention provides a novel packing composition for separation and/or analysis which permits easy capillary replacement; a process for the production of the packing composition; a method for filling a capillary with the packing composition; and electrophoretic methods (such as capillary electrophoresis) with the same. The invention relates to a packing composition for electrophoretic separation and/or analysis which contains a long self-assembly produced by dissolving a low-molecular-weight amphiphilic compound having a hydrophobic moiety and a hydrophilic moiety in water under heating and then cooling the resulting solution; a process for the production of the packing composition; a method of separation and/or analysis with the composition; and so on.

  本发明提供了一种新型的用于分离和/或分析的填充组合物，可以轻松更换毛细管；生产填充组合物的方法；用填充组合物填充毛细管的方法；以及使用相同的电泳方法（如毛细管电泳）。本发明涉及一种用于电泳分离和/或分析的填充组合物，其包含通过将具有疏水部分和亲水部分的低分子量两亲性化合物在加热水中溶解然后冷却所得的长链自组装体；生产填充组合物的方法；使用该组合物进行分离和/或分析的方法等。
• Dihydroartemisinin diploid derivative, pharmaceutical composition thereof, and application
  申请人：SOUTHEAST UNIVERSITY

  公开号：US11136339B2

  公开（公告）日：2021-10-05

  Disclosed are a dihydroartemisinin dimer derivative, a pharmaceutical composition, and an application thereof. The derivative is an artemisinin dimer used for drugs treating or preventing malaria caused by plasmodium, drugs treating autoimmune diseases such as lupus erythematosus, and anti-tumour drugs, which is a pharmaceutical composition prepared from the dihydroartemisinin dimer derivative and a pharmaceutically acceptable carrier.

  本发明公开了一种二氢青蒿素二聚体衍生物、一种药物组合物及其应用。该衍生物是一种青蒿素二聚体，用于治疗或预防由疟原虫引起的疟疾的药物、治疗红斑狼疮等自身免疫性疾病的药物和抗肿瘤药物，它是一种由二氢青蒿素二聚体衍生物和药学上可接受的载体制备而成的药物组合物。