1-Indenone, 3-hydroxy-2-(2-quinoxalinyl)-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-Indenone, 3-hydroxy-2-(2-quinoxalinyl)-
• 英文别名: 3-hydroxy-2-quinoxalin-2-ylinden-1-one
• 化学式: C₁₇H₁₀N₂O₂
• 分子量: 274.27
• InChiKey: WUFMPLCXHNQVRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Treatment of aberrant fibroblast proliferation
  申请人：Georg August Universitaet Goettingen Stiftung Oeffentlichen Rechts, Universitaetsmedizin

  公开号：US11331333B2

  公开（公告）日：2022-05-17

  Provided is a method of preventing, treating or delaying progression of a disease involving aberrant fibroblast proliferation. The method involves using a compound that reduces the level of tyrosine phosphatase activity effected by the protein EYA1A in the parenchymal organ, a nucleic acid ligase IV inhibitor, or an antisense oligonucleotide against the p53-binding protein 1 (53BP1).

  本发明提供了一种预防、治疗或延缓涉及成纤维细胞异常增殖的疾病进展的方法。该方法包括使用能降低实质器官中由蛋白 EYA1A 影响的酪氨酸磷酸酶活性水平的化合物、核酸连接酶 IV 抑制剂或针对 p53 结合蛋白 1（53BP1）的反义寡核苷酸。
• TREATMENT OF ABERRANT FIBROBLAST PROLIFERATION
  申请人：Georg-August-Universitaet Goettingen Stiftung Oeffentlichen Rechts, Universitaetsmedizin

  公开号：US20210137963A1

  公开（公告）日：2021-05-13

  Provided is a method of preventing, treating or delaying progression of a disease involving aberrant fibroblast proliferation. The method involves using a compound that reduces the level of tyrosine phosphatase activity effected by the protein EYA1A in the parenchymal organ, a nucleic acid ligase IV inhibitor, or an antisense oligonucleotide against the p53-binding protein 1 (53BP1).