4,5-dihydroxy-3-nitroso-2,7-naphthalenedisulfonic acid | 32446-22-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4,5-dihydroxy-3-nitroso-2,7-naphthalenedisulfonic acid
• 英文别名: 2-Nitroso-1,8-dihydroxynaphthalin-3,6-disulfonsaeure；4,5-dihydroxy-3-nitroso-naphthalene-2,7-disulfonic acid；4,5-Dihydroxy-3-nitroso-naphthalin-2,7-disulfonsaeure；Nitrosochromotropsaeure；8-Oxy-1-naphthochinon-(1.2)-oxim-(2)-disulfonsaeure-(3.6)；4,5-dihydroxy-3-nitrosonaphthalene-2,7-disulfonic acid
• CAS: 32446-22-3
• 化学式: C₁₀H₇NO₉S₂
• 分子量: 349.299
• InChiKey: ZZMSOJNZJNSCEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  195
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 、 sodium nitrite 作用下， 生成 4,5-dihydroxy-3-nitroso-2,7-naphthalenedisulfonic acid
  参考文献：
  名称：

  Morgan; Smith, Journal of the Chemical Society, 1921, vol. 119, p. 709

  摘要：

  DOI：

文献信息

• Brenner, Helvetica Chimica Acta, <hi>1920</hi>, vol. 3, p. 98,100
  作者：Brenner

  DOI：——

  日期：——
• AEROSOLIZED NITRITE AND NITRIC OXIDE -DONATING COMPOUNDS AND USES THEREOF
  申请人：Surber Mark W.

  公开号：US20090196930A1

  公开（公告）日：2009-08-06

  Disclosed herein are formulations of nitrite, nitrite salt, or nitrite- or nitric oxide-producing compounds suitable for aerosolization and use of such formulations for aerosol administration of nitrite, nitrite salt, or nitrite- or nitric oxide-donating compounds for the treatment of pulmonary arterial hypertension, intra-nasal or pulmonary bacterial infections, or to treat or prevent ischemic reperfusion injury of the heart, brain and organs involved in transplantation. In particular, inhaled nitrite, nitrite salt, or nitrite- or nitric oxide-donating compound specifically formulated and delivered to the respiratory tract for the indications is described. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures and manufacturing processes for production and use of the compositions described.
• AEROSOLIZED NITRITE AND NITRIC OXIDE-DONATING COMPOUNDS AND USES THEREOF
  申请人：AIRES PHARMACEUTICALS, INC.

  公开号：US20130028942A1

  公开（公告）日：2013-01-31

  Disclosed herein are formulations of nitrite, nitrite salt, or nitrite- or nitric oxide-producing compounds suitable for aerosolization and use of such formulations for aerosol administration of nitrite, nitrite salt, or nitrite- or nitric oxide-donating compounds for the treatment of pulmonary arterial hypertension, intra-nasal or pulmonary bacterial infections, or to treat or prevent ischemic reperfusion injury of the heart, brain and organs involved in transplantation. In particular, inhaled nitrite, nitrite salt, or nitrite- or nitric oxide-donating compound specifically formulated and delivered to the respiratory tract for the indications is described. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures and manufacturing processes for production and use of the compositions described.
• COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME
  申请人：Michels Aaron

  公开号：US20150038480A1

  公开（公告）日：2015-02-05

  The invention provides methods of preventing, treating or ameliorating autoimmune diseases, such as diabetes and celiac disease, by decreasing the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.
• US9629848B2
  申请人：——

  公开号：US9629848B2

  公开（公告）日：2017-04-25