(1S)-2-phenylcyclopropan-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1S)-2-phenylcyclopropan-1-amine
• 化学式: C₉H₁₁N
• 分子量: 133.19
• InChiKey: AELCINSCMGFISI-GKAPJAKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] LYSINE SPECIFIC DEMETHYLASE-1 INHIBITORS AND THEIR USE<br/>[FR] INHIBITEURS DE LA DÉMÉTHYLASE-1 SPÉCIFIQUES DE LA LYSINE, ET LEUR UTILISATION
  申请人：ORYZON GENOMICS SA

  公开号：WO2011131697A1

  公开（公告）日：2011-10-27

  The present invention relates to a compound of Formula 1, wherein: (A) is heteroaryl or aryl; each (Α'), if present, is independently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (Α') is substituted with 0, 1, 2, or 3 substituents independently chosen from halo, haloalkyl, haloalkoxy, aryl, arylalkoxy, alkyl, alkoxy, amido, -CH2C(=0)NH2, heteroaryl, cyano, sulfonyl, and sulfinyl; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is -NH-; (L) is chosen from a single bond, -CH2-, -CH2CH2-, -CH2CH2CH2-, and -CH2CH2CH2CH2-; and (D) is an aliphatic carbocyclic group or benzocycloalkyl, wherein said aliphatic carbocyclic group or said benzocycloalkyl has 0, 1, 2, or 3 substituents independently chosen from - NH2, -NH(C1-C6 alkyl), -N(C1-C6 alkyl)(C1-C6 alkyl), alkyl, halo, amido, cyano, alkoxy, haloalkyl, and haloalkoxy. (A')X-(A)-(B)-(Z)-(L)-(D) formula (I) The compounds of the invention show activity for inhibiting LSD1, which makes them useful in the treatment or prevention of diseases such as cancer.

  本发明涉及式I化合物，其中：(A)是杂芳基或芳基；每个(Α')，如果有，独立地选自芳基、芳基烷氧基、芳基烷基、杂环基、芳氧基、卤素、烷氧基、卤代烷基、环烷基、卤代烷氧基和腈，其中每个(Α')被0、1、2或3个独立选自卤素、卤代烷基、卤代烷氧基、芳基、芳基烷氧基、烷基、烷氧基、酰胺、- C(=0)NH2、杂芳基、腈、磺酰基和亚磺酰基的取代基取代；X是0、1、2或3；(B)是环丙基环，其中(A)和(Z)与(B)的不同碳原子以共价键连接；(Z)是-NH-；(L)选自单一键、-CH2-、- -、- -和- -；以及(D)是脂肪族碳环组或苯并环烷基，其中所述脂肪族碳环组或所述苯并环烷基具有0、1、2或3个独立选自-NH2、-NH(C1-C6烷基)、-N(C1-C6烷基)(C1-C6烷基)、烷基、卤素、酰胺、腈、烷氧基、卤代烷基和卤代烷氧基的取代基。式(I) (A')X-(A)-(B)-(Z)-(L)-(D)本发明的化合物对于抑制LSD1具有活性，这使得它们在治疗或预防诸如癌症等疾病方面有用。
• [EN] PHENYLCYCLOPROPYLAMINE DERIVATIVES AND THEIR MEDICAL USE<br/>[FR] DÉRIVÉS DE PHÉNYLCYCLOPROPYLAMINE ET LEUR UTILISATION MÉDICALE
  申请人：ORYZON GENOMICS SA

  公开号：WO2010084160A1

  公开（公告）日：2010-07-29

  The present invention relates to phenylcyclopropylamine derivatives. In particular, pharmaceutical compositions comprising phenylcyclopropylamine derivatives are provided. The compounds of this invention can, inter alia, be used for the treatment and the prevention of cancer as well as neurodegenerative diseases or disorders.

  本发明涉及苯基环丙胺衍生物。具体地，提供了包含苯基环丙胺衍生物的药物组合物。本发明的化合物可以用于治疗和预防癌症以及神经退行性疾病或紊乱，等等。
• [EN] LSD1 INHIBITORS<br/>[FR] INHIBITEURS DE LSD1
  申请人：MIRATI THERAPEUTICS INC

  公开号：WO2017079476A1

  公开（公告）日：2017-05-11

  The present invention relates to compounds that inhibit LSD1 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

  本发明涉及抑制LSD1活性的化合物。具体而言，本发明涉及化合物、药物组合物和使用方法，例如使用本发明的化合物和药物组合物治疗癌症的方法。
• [EN] TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSÉS MODULATEURS DE TLR2, COMPOSITIONS PHARMACEUTIQUES ET LEURS UTILISATIONS
  申请人：AXIAL THERAPEUTICS INC

  公开号：WO2021242923A1

  公开（公告）日：2021-12-02

  The present disclosure relates to compounds which modulate the activity of Toll-like receptor (TLR) proteins, including agonists or activators, partial agonists, and antagonists. Of particular interest of compounds that modulate the activity of TLR2, as well as methods of using such compounds to treat cancer and other disorders associated with a TLR2 pathway.

  本公开涉及调节Toll样受体（TLR）蛋白活性的化合物，包括激动剂或激活剂、部分激动剂和拮抗剂。特别感兴趣的是调节TLR2活性的化合物，以及使用这些化合物治疗与TLR2通路相关的癌症和其他疾病的方法。
• [EN] OXIDASE INHIBITORS AND THEIR USE<br/>[FR] INHIBITEURS D'OXYDASES ET LEUR UTILISATION
  申请人：ORYZON GENOMICS SA

  公开号：WO2010043721A1

  公开（公告）日：2010-04-22

  The invention relates to phenylcyclopropylamine acetamide derivatives and their use in treating diseases.

  该发明涉及苯基环丙胺乙酰胺衍生物及其在治疗疾病中的应用。