(NE)-N-[(2Z,4Z)-hexa-2,4-dienylidene]hydroxylamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (NE)-N-[(2Z,4Z)-hexa-2,4-dienylidene]hydroxylamine
• 化学式: C₆H₉NO
• 分子量: 111.14
• InChiKey: JVAZBPIFVPVRSK-MUVPYGFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] NOVEL 5-SUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS BENZIMIDAZOLIUM SUBSTITUÉS EN POSITION 5
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2015007516A1

  公开（公告）日：2015-01-22

  The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

  本发明涉及一般式（I）的化合物，以及其互变异构体和盐，特别是其与无机或有机酸和碱形成的药用可接受盐，具有有价值的药理特性，特别是对上皮钠通道具有抑制作用，以及其用于治疗疾病，特别是肺部和气道疾病。
• NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS
  申请人：HUTCHISON MEDIPHARMA LIMITED

  公开号：US20150291593A1

  公开（公告）日：2015-10-15

  Provided are novel heteroaryl and heterocycle compounds of formula (I-1), (I-2) or (I-3) and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI 3 K and for treating inflammatory and autoimmune disorders diseases and cancer.

  提供的是式(I-1)、(I-2)或(I-3)的新型杂环和杂环芳基化合物，以及包含它们的药物组合物、使用方法和方法，用于抑制PI3K活性和治疗炎症、自身免疫性疾病和癌症。
• One-pot process for the synthesis of dalfampridine
  申请人：Procos S.p.A.

  公开号：EP2394994A1

  公开（公告）日：2011-12-14

  A process for the preparation of Dalfampridine (1), 4-aminopyridine, starting from 4-pyridinecarbonitrile using a one-pot procedure. Said process is carried out with no need for isolating intermediates and is particularly advantageous as far as environment, yields, productivity and purity of the resulting product are concerned, both in the reaction mixture and in the isolated crystal.

  一种以 4-吡啶甲腈为起始原料，采用一锅法制备 4-氨基吡啶，即 Dalfampridine (1)的工艺。 该工艺无需分离中间产物，在反应混合物和分离晶体的环境、产量、生产率和所得产物的纯度方面都具有特别的优势。
• BICYCLIC RING SYSTEM SUBSTITUTED SULFONAMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2651932B1

  公开（公告）日：2015-11-25
• SUBSTITUTED PIPERIDINES AS GPR119 MODULATORS FOR THE TREATMENT OF METABOLIC DISORDERS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2718288B1

  公开（公告）日：2015-03-11